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Page 1
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
CRASH-2 trial collaborators; Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. CRASH-2 trial collaborators, et al. Lancet. 2010 Jul 3;376(9734):23-32. doi: 10.1016/S0140-6736(10)60835-5. Epub 2010 Jun 14. Lancet. 2010. PMID: 20554319 Clinical Trial.
All-cause mortality was significantly reduced with tranexamic acid (1463 [14.5%] tranexamic acid group vs 1613 [16.0%] placebo group; relative risk 0.91, 95% CI 0.85-0.97; p=0.0035). The risk of death due to bleeding was significantly reduced (489 [4.9%] vs 574 [5.7%]; rel …
All-cause mortality was significantly reduced with tranexamic acid (1463 [14.5%] tranexamic acid group vs 1613 [16.0%] placebo group; relati …
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. CRASH-2 collaborators, et al. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X. Lancet. 2011. PMID: 21439633 Clinical Trial.
Treatment given between 1 and 3 h also reduced the risk of death due to bleeding (147/3037 [4.8%] vs 184/2996 [6.1%]; RR 0.79, 0.64-0.97; p=0.03). Treatment given after 3 h seemed to increase the risk of death due to bleeding (144/3272 [4.4%] vs 103/3362 [3.1%]; RR 1.44, 1 …
Treatment given between 1 and 3 h also reduced the risk of death due to bleeding (147/3037 [4.8%] vs 184/2996 [6.1%]; RR 0.79, 0.64-0.97; …
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Velasco ER, Florido A, Flores Á, Senabre E, Gomez-Gomez A, Torres A, Roca A, Norrholm S, Newman EL, Das P, Ross RA, Lori A, Pozo OJ, Ressler KJ, Garcia-Esteve LL, Jovanovic T, Andero R. Velasco ER, et al. Nat Commun. 2022 Jul 28;13(1):4374. doi: 10.1038/s41467-022-31442-w. Nat Commun. 2022. PMID: 35902577 Free PMC article.
Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging.
Doering S, McCullough A, Gordon BA, Chen CD, McKay N, Hobbs D, Keefe S, Flores S, Scott J, Smith H, Jarman S, Jackson K, Hornbeck RC, Ances BM, Xiong C, Aschenbrenner AJ, Hassenstab J, Cruchaga C, Daniels A, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN) Investigators; Morris JC, Benzinger TLS. Doering S, et al. EBioMedicine. 2024 Mar 28;103:105080. doi: 10.1016/j.ebiom.2024.105080. Online ahead of print. EBioMedicine. 2024. PMID: 38552342 Free PMC article.

FINDINGS: We found both tau metrics significantly elevated across increasing disease stages (p < 0.0001) and as a function of increasing amyloid burden for participants with preclinical (p < 0.0001, p = 0.0056) and symptomatic (p = 0.010, p

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FINDINGS: We found both tau metrics significantly elevated across increasing disease stages (p < 0.0001) and as a function of incr

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The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis.
Flores RJ, Flaherty KR, Jin Z, Bokhari S. Flores RJ, et al. J Nucl Cardiol. 2020 Dec;27(6):2003-2010. doi: 10.1007/s12350-018-01504-y. Epub 2018 Nov 12. J Nucl Cardiol. 2020. PMID: 30421379
Poisson regression analysis revealed that max SUV, mean SUV, as well as mean basal SUV, and LVEF were significantly associated with total cardiac events. Max SUV odds ratio (OR) = 1.068 (95% CI 1.024-1.114, P = 0.002), mean SUV OR = 1.059 (95% CI 1.008-1.113, P = 0. …
Poisson regression analysis revealed that max SUV, mean SUV, as well as mean basal SUV, and LVEF were significantly associated with total ca …
Undernutrition reduces the body weight and testicular size of bucks exposed to long days but not their ability to stimulate reproduction of seasonally anestrous goats.
Delgadillo JA, Lemière A, Flores JA, Bedos M, Hernández H, Vielma J, Guerrero-Cervantes M, Zarazaga LA, Keller M, Chemineau P. Delgadillo JA, et al. Animal. 2020 Dec;14(12):2562-2569. doi: 10.1017/S1751731120001329. Epub 2020 Jun 16. Animal. 2020. PMID: 32539906 Free article.

In experiment 1, a treatment by time interaction was detected for BW, scrotal circumference and odor intensity changes (P < 0.001). The BWs of well-fed bucks were greater than those of the undernourished bucks from October to May (P < 0.01), as were the scrota

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In experiment 1, a treatment by time interaction was detected for BW, scrotal circumference and odor intensity changes (P < 0.001)

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[The effect of an educational intervention on the metabolic control of diabetic patients].
Olivares D, Flores J. Olivares D, et al. Rev Med Chil. 2019 Aug;147(8):1024-1028. doi: 10.4067/S0034-98872019000801024. Rev Med Chil. 2019. PMID: 31859967 Free article. Spanish.

The proportion of compensated patients, defined as those having a glycosylated hemoglobin between 7 and 9%, increased significantly after the educational intervention (chi2 = 7.9 p < 0.01, odds ratio: 0.2). CONCLUSIONS: A educational intervention in patients with insuli

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The proportion of compensated patients, defined as those having a glycosylated hemoglobin between 7 and 9%, increased significantly after th …
Efficiency of the male effect with photostimulated bucks does not depend on their familiarity with goats.
Muñoz AL, Bedos M, Aroña RM, Flores JA, Hernández H, Moussu C, Briefer EF, Chemineau P, Keller M, Delgadillo JA. Muñoz AL, et al. Physiol Behav. 2016 May 1;158:137-42. doi: 10.1016/j.physbeh.2016.02.037. Epub 2016 Mar 3. Physiol Behav. 2016. PMID: 26948162
In each test, goats in contact with novel males displayed more distress bleats, escapes, head butts, and sniffing than those in contact with familiar males (P<0.05). In Experiment 2, we used sexually inactive (n=4 control males), and sexually active males (n=4 photostim …
In each test, goats in contact with novel males displayed more distress bleats, escapes, head butts, and sniffing than those in contact with …
Feeding corn during the last 12 days of gestation improved colostrum production and neonatal activity in goats grazing subtropical semi-arid rangeland.
Ramírez-Vera S, Terrazas A, Delgadillo JA, Serafín N, Flores JA, Elizundia JM, Hernández H. Ramírez-Vera S, et al. J Anim Sci. 2012 Jul;90(7):2362-70. doi: 10.2527/jas.2011-4306. Epub 2012 Jan 20. J Anim Sci. 2012. PMID: 22266993
From 6 to 10 h postpartum, contents of colostrum protein and solids not fat were less (P 0.012) whereas lactose contents were greater (P = 0.035) in the SC does than in control does. ...A significant decrease (P = 0.001) in plasma progesterone concentrations …
From 6 to 10 h postpartum, contents of colostrum protein and solids not fat were less (P 0.012) whereas lactose contents were greater …
Nutritional supplementation improves the sexual response of bucks exposed to long days in semi-extensive management and their ability to stimulate reproduction in goats.
Delgadillo JA, Sifuentes PI, Flores MJ, Espinoza-Flores LA, Andrade-Esparza JD, Hernández H, Keller M, Chemineau P. Delgadillo JA, et al. Animal. 2021 Feb;15(2):100114. doi: 10.1016/j.animal.2020.100114. Epub 2020 Dec 23. Animal. 2021. PMID: 33573958 Free article.

Pregnancy rates were greater in the goats housed with the long-day group than those housed with the control group (P < 0.01). However, pregnancy rates did not differ between the long-day confined group (89%) and long-day+supplementation group (70%; P = 0.09), but

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Pregnancy rates were greater in the goats housed with the long-day group than those housed with the control group (P < 0.01). Howe

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21 results