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Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.
Gillard M, Chatelain P, Fuks B. Gillard M, et al. Eur J Pharmacol. 2006 Apr 24;536(1-2):102-8. doi: 10.1016/j.ejphar.2006.02.022. Epub 2006 Mar 10. Eur J Pharmacol. 2006. PMID: 16556440
The results showed that the binding properties of levetiracetam and [3H]ucb 30889, an analogue that was previously characterized as a suitable ligand for levetiracetam binding site/SV2A in rat brain [Gillard, M., Fuks, B., Michel, P., Vertongen, P., Massingham, R. C …
The results showed that the binding properties of levetiracetam and [3H]ucb 30889, an analogue that was previously characterized as a suitab …
A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3.
Paul MS, Michener SL, Pan H, Chan H, Pfliger JM, Rosenfeld JA, Lerma VC, Tran A, Longley MA, Lewis RA, Weisz-Hubshman M, Bekheirnia MR, Bekheirnia N, Massingham L, Zech M, Wagner M, Engels H, Cremer K, Mangold E, Peters S, Trautmann J, Mester JL, Guillen Sacoto MJ, Person R, McDonnell PP, Cohen SR, Lusk L, Cohen ASA, Le Pichon JB, Pastinen T, Zhou D, Engleman K, Racine C, Faivre L, Moutton S, Denommé-Pichon AS, Koh HY, Poduri A, Bolton J, Knopp C, Julia Suh DS, Maier A, Toosi MB, Karimiani EG, Maroofian R, Schaefer GB, Ramakumaran V, Vasudevan P, Prasad C, Osmond M, Schuhmann S, Vasileiou G, Russ-Hall S, Scheffer IE, Carvill GL, Mefford H; Undiagnosed Diseases Network; Bacino CA, Lee BH, Chao HT. Paul MS, et al. Am J Hum Genet. 2024 Jan 4;111(1):96-118. doi: 10.1016/j.ajhg.2023.12.004. Am J Hum Genet. 2024. PMID: 38181735
PhyloSim - Monte Carlo simulation of sequence evolution in the R statistical computing environment.
Sipos B, Massingham T, Jordan GE, Goldman N. Sipos B, et al. BMC Bioinformatics. 2011 Apr 19;12:104. doi: 10.1186/1471-2105-12-104. BMC Bioinformatics. 2011. PMID: 21504561 Free PMC article.
RESULTS: PhyloSim is an extensible framework for the Monte Carlo simulation of sequence evolution, written in R, using the Gillespie algorithm to integrate the actions of many concurrent processes such as substitutions, insertions and deletions. ...User-defined complex pat …
RESULTS: PhyloSim is an extensible framework for the Monte Carlo simulation of sequence evolution, written in R, using the Gillespie …
The designated record set for clinical genetic and genomic testing: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).
Tayeh MK, Chen M, Fullerton SM, Gonzales PR, Huang SJ, Massingham LJ, O'Daniel JM, Stewart DR, Stiles AR, Evans BJ; ACMG Laboratory Quality Assurance Committee and the ACMG Social, Ethical and Legal Issues Committee. Electronic address: documents@acmg.net. Tayeh MK, et al. Genet Med. 2023 Mar;25(3):100342. doi: 10.1016/j.gim.2022.11.010. Epub 2022 Dec 22. Genet Med. 2023. PMID: 36547466 Free article. No abstract available.
Experimental design criteria in phylogenetics: where to add taxa.
Geuten K, Massingham T, Darius P, Smets E, Goldman N. Geuten K, et al. Syst Biol. 2007 Aug;56(4):609-22. doi: 10.1080/10635150701499563. Syst Biol. 2007. PMID: 17654365
Here we investigate the use of the Fisher information matrix to decide between candidate positions for adding a taxon to a fixed topology, and introduce a parameter transformation that permits comparison of these different designs. This extension to Goldman (1998. Proc. R. …
Here we investigate the use of the Fisher information matrix to decide between candidate positions for adding a taxon to a fixed topology, a …
Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).
Gupta A, Chatelain P, Massingham R, Jonsson EN, Hammarlund-Udenaes M. Gupta A, et al. Drug Metab Dispos. 2006 Feb;34(2):318-23. doi: 10.1124/dmd.105.007211. Epub 2005 Nov 22. Drug Metab Dispos. 2006. PMID: 16303872
The stereoselective brain distribution indicated by the K(p) of 0.22 and 0.04 for S- and R-CZE, respectively, was caused by different binding to plasma proteins. The transport of the CZE enantiomers across the BBB was not stereoselective, since the K(p,uu) was 0.17 and 0.1 …
The stereoselective brain distribution indicated by the K(p) of 0.22 and 0.04 for S- and R-CZE, respectively, was caused by different …
A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold.
Diouf O, Gadeau S, Chellé F, Gelbcke M, Talaga P, Christophe B, Gillard M, Massingham R, Guyaux M. Diouf O, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2535-9. doi: 10.1016/s0960-894x(02)00487-0. Bioorg Med Chem Lett. 2002. PMID: 12182854
Chemical modulations provided molecules with K(i) for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the human M2-R. ...
Chemical modulations provided molecules with K(i) for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the hu …
11 results