Pregnane glycosides from Gymnema inodorum and their α-glucosidase inhibitory activity

Nat Prod Res. 2021 Jul;35(13):2157-2163. doi: 10.1080/14786419.2019.1663517. Epub 2019 Sep 11.

Abstract

Two new pregnane glycosides, gyminosides A and B (1 and 2) and three known, tinctoroside B (3), tinctoroside C (4), and gymnepregoside F (5) were isolated from the leaves of Gymnema inodorum (Lour.) Decne. Their structures were elucidated by physical and chemical methods and comparing with those reported in the literature. All these compounds were evaluated for α-glucosidase assay. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 63.7 ± 3.9% at the concentration of 200 μM. Compounds 1-4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 40.0 to 52.1%.

Keywords: Asclepiadacaea; Gymnema inodorum; gyminoside; pregnane; α-glucosidase.

MeSH terms

  • Carbon-13 Magnetic Resonance Spectroscopy
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology*
  • Gymnema / chemistry*
  • Plant Leaves / chemistry
  • Pregnanes / chemistry
  • Pregnanes / isolation & purification*
  • Pregnanes / pharmacology*
  • Proton Magnetic Resonance Spectroscopy
  • alpha-Glucosidases / metabolism

Substances

  • Glycoside Hydrolase Inhibitors
  • Glycosides
  • Pregnanes
  • pregnane glycoside
  • alpha-Glucosidases