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Page 1
Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study.
Fang S, Yarmolinsky J, Gill D, Bull CJ, Perks CM; PRACTICAL Consortium; Davey Smith G, Gaunt TR, Richardson TG. Fang S, et al. PLoS Med. 2023 Jan 3;20(1):e1003988. doi: 10.1371/journal.pmed.1003988. eCollection 2023 Jan. PLoS Med. 2023. PMID: 36595504 Free PMC article.
Validation analyses were performed using genetic instruments from an LDL-c GWAS conducted on male UK Biobank participants of European ancestry (N = 201,678), as well as instruments selected based on liver-derived gene expression and circulation plasma levels of targets. We …
Validation analyses were performed using genetic instruments from an LDL-c GWAS conducted on male UK Biobank participants of European ancest …
Editorial: Immunogenicity of Proteins Used as Therapeutics.
Sauna ZE, Richards SM, Maillere B, Jury EC, Rosenberg AS. Sauna ZE, et al. Front Immunol. 2020 Oct 29;11:614856. doi: 10.3389/fimmu.2020.614856. eCollection 2020. Front Immunol. 2020. PMID: 33193460 Free PMC article. No abstract available.
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Our multi-omics approach is based on (a) 2114 human post-mortem brain transcriptomics to identify differentially expressed genes; (b) in silico metabolic flux analysis on context-specific metabolic networks identified differential reaction fluxes; (c) multimodal neuroimaging anal …
Our multi-omics approach is based on (a) 2114 human post-mortem brain transcriptomics to identify differentially expressed genes; (b) in sil …
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM. Garnock-Jones KP, et al. Paediatr Drugs. 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. Paediatr Drugs. 2009. PMID: 19445548 Review.
Atomoxetine is rapidly absorbed, and demonstrates dose-proportional increases in plasma exposure. It undergoes extensive biotransformation, which is affected by poor metabolism by cytochrome P450 (CYP) 2D6 in a small percentage of the population; these patients have greate …
Atomoxetine is rapidly absorbed, and demonstrates dose-proportional increases in plasma exposure. It undergoes extensive biotransform …
New Emerging Developments of Platelets in Transfusion Medicine.
Stolla M, Kapur R, Semple JW. Stolla M, et al. Transfus Med Rev. 2020 Oct;34(4):207-208. doi: 10.1016/j.tmrv.2020.09.009. Epub 2020 Oct 7. Transfus Med Rev. 2020. PMID: 33129605 Free PMC article. No abstract available.
Autoimmune hepatitis-is histology conclusive?
Beer A, Dienes HP. Beer A, et al. Ann Transl Med. 2021 Apr;9(8):733. doi: 10.21037/atm-20-5084. Ann Transl Med. 2021. PMID: 33987431 Free PMC article. Review.
Histopathology shows moderate to severe inflammatory infiltrates with abundant plasma cells in the enlarged portal tracts with interface hepatitis and moderate to severe necroinflammatory lesions in the lobules with lymphoplasmacytic reaction. ...
Histopathology shows moderate to severe inflammatory infiltrates with abundant plasma cells in the enlarged portal tracts with interf …
Dried plasma: An urgent priority for trauma readiness.
Polk TM, Gurney JM, Riggs LE, Cannon JW, Cap AP, Friedrichs PA. Polk TM, et al. J Trauma Acute Care Surg. 2023 Aug 1;95(2S Suppl 1):S4-S6. doi: 10.1097/TA.0000000000004073. Epub 2023 Jun 6. J Trauma Acute Care Surg. 2023. PMID: 37277904 Free PMC article. No abstract available.
Management of asymptomatic carotid stenosis.
Spence JD. Spence JD. Ann Transl Med. 2020 Oct;8(19):1262. doi: 10.21037/atm-20-975. Ann Transl Med. 2020. PMID: 33178794 Free PMC article. Review.
All patients with ACS should receive intensive lipid-lowering therapy, should have their blood pressure well controlled, and should receive B vitamins for lowering of plasma total homocysteine (tHcy) if levels are high; a commonly missed cause of elevated tHcy is metabolic …
All patients with ACS should receive intensive lipid-lowering therapy, should have their blood pressure well controlled, and should receive …
Optimal diuretic strategies in heart failure.
Suri SS, Pamboukian SV. Suri SS, et al. Ann Transl Med. 2021 Mar;9(6):517. doi: 10.21037/atm-20-4600. Ann Transl Med. 2021. PMID: 33850914 Free PMC article. Review.
The pathology is characterized by hemodynamic abnormalities that result in autonomic imbalance with an increase in sympathetic activity, withdrawal of vagal activity and neurohormonal activation (NA) resulting in increased plasma volume in the setting of decreased sodium e …
The pathology is characterized by hemodynamic abnormalities that result in autonomic imbalance with an increase in sympathetic activity, wit …
Dairy consumption and hepatocellular carcinoma risk.
Melnik BC. Melnik BC. Ann Transl Med. 2021 Apr;9(8):736. doi: 10.21037/atm-2020-ubih-06. Ann Transl Med. 2021. PMID: 33987434 Free PMC article. Review.
Chronic alcohol consumption as well as type 2 diabetes mellitus (T2DM), two HCC-related conditions, increase BCAA plasma levels. In HCC, mTORC1 is further hyperactivated due to RAB1 mutations as well as impaired hepatic BCAA catabolism, a metabolic hallmark of T2DM. ...
Chronic alcohol consumption as well as type 2 diabetes mellitus (T2DM), two HCC-related conditions, increase BCAA plasma levels. In H …
53 results