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Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.
Timm KN, Hu DE, Williams M, Wright AJ, Kettunen MI, Kennedy BWC, Larkin TJ, Dzien P, Marco-Rius I, Bohndiek SE, Brindle KM. Timm KN, et al. Among authors: dzien p. J Biol Chem. 2017 Feb 3;292(5):1737-1748. doi: 10.1074/jbc.M116.761536. Epub 2016 Dec 19. J Biol Chem. 2017. PMID: 27994059 Free PMC article.
(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Dzien P, Tee SS, Kettunen MI, Lyons SK, Larkin TJ, Timm KN, Hu DE, Wright A, Rodrigues TB, Serrao EM, Marco-Rius I, Mannion E, D'Santos P, Kennedy BW, Brindle KM. Dzien P, et al. Magn Reson Med. 2016 Aug;76(2):391-401. doi: 10.1002/mrm.25879. Epub 2015 Sep 21. Magn Reson Med. 2016. PMID: 26388418 Free PMC article.
Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
Vincent EE, Elder DJ, O'Flaherty L, Pardo OE, Dzien P, Phillips L, Morgan C, Pawade J, May MT, Sohail M, Hetzel MR, Seckl MJ, Tavaré JM. Vincent EE, et al. Among authors: dzien p. PLoS One. 2014 Dec 8;9(12):e114725. doi: 10.1371/journal.pone.0114725. eCollection 2014. PLoS One. 2014. PMID: 25486534 Free PMC article.