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Showing results for philippe herein
Your search for Philippe Hereil retrieved no results
Alcohol Consumption and Obesity: An Update.
Traversy G, Chaput JP. Traversy G, et al. Curr Obes Rep. 2015 Mar;4(1):122-30. doi: 10.1007/s13679-014-0129-4. Curr Obes Rep. 2015. PMID: 25741455 Free PMC article. Review.
In conclusion, despite the important limitations of current studies, it is reasonable to say that alcohol intake may be a risk factor for obesity in some individuals, likely based on a multitude of factors, some of which are discussed herein....
In conclusion, despite the important limitations of current studies, it is reasonable to say that alcohol intake may be a risk factor for ob …
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP. Houles T, et al. Nat Commun. 2022 Oct 29;13(1):6457. doi: 10.1038/s41467-022-34179-8. Nat Commun. 2022. PMID: 36309522 Free PMC article.
Nearly all melanomas harbor mutations that activate the RAS/mitogen-activated protein kinase (MAPK) pathway, which contributes to drug resistance via poorly described mechanisms. Herein we show that the RAS/MAPK pathway regulates the activity of cyclin-dependent kinase 12 …
Nearly all melanomas harbor mutations that activate the RAS/mitogen-activated protein kinase (MAPK) pathway, which contributes to drug resis …
Loss of hepatocyte identity following aberrant YAP activation: A key mechanism in alcoholic hepatitis.
Bou Saleh M, Louvet A, Ntandja-Wandji LC, Boleslawski E, Gnemmi V, Lassailly G, Truant S, Maggiotto F, Ningarhari M, Artru F, Anglo E, Sancho-Bru P, Corlu A, Argemi J, Dubois-Chevalier J, Dharancy S, Eeckhoute J, Bataller R, Mathurin P, Dubuquoy L. Bou Saleh M, et al. J Hepatol. 2021 Oct;75(4):912-923. doi: 10.1016/j.jhep.2021.05.041. Epub 2021 Jun 12. J Hepatol. 2021. PMID: 34129887 Free article.
LAY SUMMARY: Alcoholic hepatitis is characterized by inflammation and a life-threatening alteration of liver regeneration, although the mechanisms behind this have not been identified. Herein, we show that liver samples from patients with alcoholic hepatitis are characteri …
LAY SUMMARY: Alcoholic hepatitis is characterized by inflammation and a life-threatening alteration of liver regeneration, although the mech …
Oxidative stress response pathways in fungi.
Yaakoub H, Mina S, Calenda A, Bouchara JP, Papon N. Yaakoub H, et al. Cell Mol Life Sci. 2022 Jun 1;79(6):333. doi: 10.1007/s00018-022-04353-8. Cell Mol Life Sci. 2022. PMID: 35648225 Review.
Data have been accumulating on the roles of the HOG pathway and Yap1- and Skn7-related pathways in mounting distinct and robust responses in fungi upon exposure to oxidative stress. Herein, we review recent and most relevant studies reporting the contribution of each of th …
Data have been accumulating on the roles of the HOG pathway and Yap1- and Skn7-related pathways in mounting distinct and robust responses in …
Non-Photoinduced Biological Properties of Verteporfin.
Gibault F, Corvaisier M, Bailly F, Huet G, Melnyk P, Cotelle P. Gibault F, et al. Curr Med Chem. 2016;23(11):1171-84. doi: 10.2174/0929867323666160316125048. Curr Med Chem. 2016. PMID: 26980565 Review.
However, YAP was also found to be closely connected to autophagy, mitochondria and reactive oxygen/nitrogen species. We herein, review the recent studies where VP was used without photoactivation as a YAP/TEAD inhibitor or protein oligomerization promoter, focusing on its …
However, YAP was also found to be closely connected to autophagy, mitochondria and reactive oxygen/nitrogen species. We herein, revie …
Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
Bai G, O'Connell TN, Brodney MA, Butler CR, Czabaniuk LC, Gilbert AM, LaChapelle EA, Li C, McAllister LA, Ogilvie K, Philippe L, Salomon-Ferrer R, Shapiro MJ, Starr JT, Uccello DP, Withka JM, Yan J, Brown MF. Bai G, et al. ACS Med Chem Lett. 2021 Sep 30;12(10):1585-1588. doi: 10.1021/acsmedchemlett.1c00402. eCollection 2021 Oct 14. ACS Med Chem Lett. 2021. PMID: 34676040 Free PMC article.
The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide group. ...
The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidin …
27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor.
Ayadi S, Friedrichs S, Soulès R, Pucheu L, Lütjohann D, Silvente-Poirot S, Poirot M, de Medina P. Ayadi S, et al. J Lipid Res. 2023 Dec;64(12):100479. doi: 10.1016/j.jlr.2023.100479. Epub 2023 Nov 20. J Lipid Res. 2023. PMID: 37981011 Free PMC article.
It is currently unknown whether OCDO and its precursors can be hydroxylated at position C27 by CYP27A1, as is the impact of such modification on the proliferation of ER(+) and TN BC cells. We investigated, herein, whether 27H-5,6-ECs ((25R)-5,6-epoxycholestan-3beta,26-diol …
It is currently unknown whether OCDO and its precursors can be hydroxylated at position C27 by CYP27A1, as is the impact of such modificatio …
USP15: a review of its implication in immune and inflammatory processes and tumor progression.
Georges A, Gros P, Fodil N. Georges A, et al. Genes Immun. 2021 May;22(1):12-23. doi: 10.1038/s41435-021-00125-9. Epub 2021 Apr 6. Genes Immun. 2021. PMID: 33824497 Review.
Recent studies have shown that USP15 plays a critical role in regulating many aspects of immune and inflammatory function of leukocytes in response to a broad range of infectious and autoimmune insults and following tissue damage. USP15 regulated pathways reviewed herein i …
Recent studies have shown that USP15 plays a critical role in regulating many aspects of immune and inflammatory function of leukocytes in r …
Transforming drug discovery with a high-throughput AI-powered platform: A 5-year experience with Patrimony.
Blaudin de Thé FX, Baudier C, Andrade Pereira R, Lefebvre C, Moingeon P; Patrimony Working Group. Blaudin de Thé FX, et al. Drug Discov Today. 2023 Nov;28(11):103772. doi: 10.1016/j.drudis.2023.103772. Epub 2023 Sep 16. Drug Discov Today. 2023. PMID: 37717933 Review.
Patrimony has enabled researchers to prioritize therapeutic targets based on a deep understanding of the pathophysiology of immuno-inflammatory diseases. Herein, we share our experience regarding main challenges and critical success factors faced when industrializing the p …
Patrimony has enabled researchers to prioritize therapeutic targets based on a deep understanding of the pathophysiology of immuno-inflammat …
[New pets, allergens and allergic dermatitis].
Brajon D, Waton J, Schmutz JL, Barbaud A. Brajon D, et al. Ann Dermatol Venereol. 2014 Oct;141(10):581-7. doi: 10.1016/j.annder.2014.06.014. Epub 2014 Aug 5. Ann Dermatol Venereol. 2014. PMID: 25288060 Review. French.
While the most common allergies are respiratory, allergic skin reactions, both immediate and delayed, may also result from contact with these new allergens. The animal itself or its environment may be the cause. Herein, we review NPs and reports of allergic dermatitis asso …
While the most common allergies are respiratory, allergic skin reactions, both immediate and delayed, may also result from contact with thes …
123 results