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Showing results for phil a b. liver
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Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane.
Teslenko I, Trudeau J, Luo S, Watson CJW, Chen G, Truica CI, Lazarus P. Teslenko I, et al. J Pharmacol Exp Ther. 2022 Sep;382(3):327-334. doi: 10.1124/jpet.122.001232. Epub 2022 Jul 6. J Pharmacol Exp Ther. 2022. PMID: 35793834 Free PMC article.
The goal of the present study was to investigate the effects of genetic variation in EXE-metabolizing GST enzymes on overall EXE metabolism. Ex vivo assays examining human liver cytosols from 75 subjects revealed the GSTA1 *B*B genotype was associated with si …
The goal of the present study was to investigate the effects of genetic variation in EXE-metabolizing GST enzymes on overall EXE metabolism. …
Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11).
Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK. Potter PM, et al. Cancer Res. 1998 Jun 15;58(12):2646-51. Cancer Res. 1998. PMID: 9635592
NH2-terminal amino acid sequencing of a purified rabbit CE allowed the design of redundant oligonucleotides to perform PCR from rabbit liver cDNA. DNA sequencing of the PCR product confirmed the identity of the clone, and after both 5' and 3' rapid amplification of cDNA en …
NH2-terminal amino acid sequencing of a purified rabbit CE allowed the design of redundant oligonucleotides to perform PCR from rabbit li …
Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker.
Tariq S, Tariq S, Hussain S, Baig M. Tariq S, et al. Pak J Med Sci. 2020 Sep-Oct;36(6):1325-1329. doi: 10.12669/pjms.36.6.2678. Pak J Med Sci. 2020. PMID: 32968402 Free PMC article.
OBJECTIVE: To determine the association of serum osteoprotegerin (OPG) with the severity of chronic liver disease in female patients. METHODS: This case-control study was conducted in Madina Teaching Hospital from 2019-2020.An institutional review board of University Medic …
OBJECTIVE: To determine the association of serum osteoprotegerin (OPG) with the severity of chronic liver disease in female patients. …
3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury.
Lee PJ, Park HJ, Cho N, Kim HP. Lee PJ, et al. Molecules. 2018 Oct 31;23(11):2833. doi: 10.3390/molecules23112833. Molecules. 2018. PMID: 30384491 Free PMC article.
Hepatic stellate cells (HSCs) are involved in the pathogenesis of liver fibrosis. Resveratrol, 3,5,4'-trihydroxystilbene, is a dietary polyphenol found in natural food products. ...DEHR ameliorates liver fibrosis in vitro and in vivo, possibly through a mechanism in …
Hepatic stellate cells (HSCs) are involved in the pathogenesis of liver fibrosis. Resveratrol, 3,5,4'-trihydroxystilbene, is a dietar …
Differential Immune Landscape of Hepatocellular Carcinoma Suggests Potential role of Macrophages in Hepatocarcinogenesis.
Shafique Y, Qureshi MA, Khan S, Mirza T. Shafique Y, et al. Pak J Med Sci. 2021 May-Jun;37(3):858-862. doi: 10.12669/pjms.37.3.2973. Pak J Med Sci. 2021. PMID: 34104178 Free PMC article.
METHODS: This cross-sectional study was conducted during 2017-2019 at the Dow University of Health Sciences Karachi. A total of 42 subsequent patients undergoing liver biopsy/resection and diagnosed with hepatocellular carcinoma were included in the study. ...CONCLUSION: W …
METHODS: This cross-sectional study was conducted during 2017-2019 at the Dow University of Health Sciences Karachi. A total of 42 subsequen …
Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota.
Kao AC, Spitzer S, Anthony DC, Lennox B, Burnet PWJ. Kao AC, et al. Transl Psychiatry. 2018 Mar 15;8(1):66. doi: 10.1038/s41398-018-0116-8. Transl Psychiatry. 2018. PMID: 29540664 Free PMC article.
The abundance of WAT GPR43 mRNA was reduced by olanzapine, only in the absence of B-GOS(). Co-administration of B-GOS() and olanzapine also elevated plasma TNFalpha, which is reported to influence lipid metabolism. Finally, B-GOS() elevated faecal Bifidobacte …
The abundance of WAT GPR43 mRNA was reduced by olanzapine, only in the absence of B-GOS(). Co-administration of B-GOS() and ol …
Ameliorating effect of Allium Sativum on high-fat diet induced fatty liver in albino rats.
Qamar A, Usmani A, Waqar H, Siddiqui A, Kumar H. Qamar A, et al. Pak J Med Sci. 2016 Mar-Apr;32(2):403-7. doi: 10.12669/pjms.322.9025. Pak J Med Sci. 2016. PMID: 27182249 Free PMC article.
The groups were further divided on the basis of duration of treatment, four weeks and eight weeks respectively. The rats were sacrificed, liver removed, weighed and relative liver weight calculated. Hepatic tissue was processed and tissue slides stained with haemato …
The groups were further divided on the basis of duration of treatment, four weeks and eight weeks respectively. The rats were sacrificed, …
Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL.
Kozlovich S, Chen G, Watson CJW, Blot WJ, Lazarus P. Kozlovich S, et al. Drug Metab Dispos. 2019 Dec;47(12):1388-1396. doi: 10.1124/dmd.119.088351. Epub 2019 Oct 2. Drug Metab Dispos. 2019. PMID: 31578206 Free PMC article.
UGTs 1A9, 1A10, 2A1, 2A2, 2A3, 2B4, 2B7, and 2B17 all exhibited glucuronidating activity against both l- and d-menthol. In human liver microsomes, both l- and d-menthol inhibited the formation of each NNAL-Gluc, with a stereospecific difference observed between the formati …
UGTs 1A9, 1A10, 2A1, 2A2, 2A3, 2B4, 2B7, and 2B17 all exhibited glucuronidating activity against both l- and d-menthol. In human liver …
Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes.
Abro MUR, Butt A, Baqa K, Waris N, Khalid M, Fawwad A. Abro MUR, et al. Pak J Med Sci. 2018 Jul-Aug;34(4):839-843. doi: 10.12669/pjms.344.15206. Pak J Med Sci. 2018. PMID: 30190738 Free PMC article.
OBJECTIVES: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. METHODS: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. ...Subjects were divided into two …
OBJECTIVES: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. METHODS: This retrospective d …
Amelioration of acetaminophen induced hepatotoxicity by methanolic extract of pomegranate peels in rats.
Ahmad N, Tahir M, Lone KP. Ahmad N, et al. J Pak Med Assoc. 2016 Jul;66(7):859-63. J Pak Med Assoc. 2016. PMID: 27427136
Control group A was given normal saline (5ml/kg), whereas group B and C were given 750mg/kg acetaminophen intraperitoneally dissolved in normal saline (5ml/kg) on 1st day of experiment. ...RESULTS: There were 24 rats weighing 17525gm each. Each group had 8(33.3%) rats. Mea …
Control group A was given normal saline (5ml/kg), whereas group B and C were given 750mg/kg acetaminophen intraperitoneally dissolved …
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