Broad-spectrum antimicrobial epiphytic and endophytic fungi from marine organisms: isolation, bioassay and taxonomy

Yi Zhang; Jun Mu; Yan Feng; Yue Kang; Jia Zhang; Peng-Juan Gu; Yu Wang; Li-Fang Ma; Yan-Hua Zhu

doi:10.3390/md7020097

Broad-spectrum antimicrobial epiphytic and endophytic fungi from marine organisms: isolation, bioassay and taxonomy

Mar Drugs. 2009 Apr 17;7(2):97-112. doi: 10.3390/md7020097.

Authors

Yi Zhang¹, Jun Mu, Yan Feng, Yue Kang, Jia Zhang, Peng-Juan Gu, Yu Wang, Li-Fang Ma, Yan-Hua Zhu

Affiliation

¹ Department of Biotechnology, School of Environmental and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, P.R. China. zhangyi@djtu.edu.cn

Abstract

In the search for new marine derived antibiotics, 43 epi- and endophytic fungal strains were isolated from the surface or the inner tissue of different marine plants and invertebrates. Through preliminary and secondary screening, 10 of them were found to be able to produce broad-spectrum antimicrobial metabolites. By morphological and molecular biological methods, three active strains were characterized to be Penicillium glabrum, Fusarium oxysporum, and Alternaria alternata.

Keywords: Epi- and endophytic; antimicrobial activity; marine derived fungi; taxonomy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Bacteria / drug effects
Candida albicans / drug effects
DNA, Ribosomal Spacer / genetics
Eukaryota / microbiology*
Fungi / classification
Fungi / cytology
Fungi / genetics
Fungi / isolation & purification*
Fungi / metabolism*
Invertebrates / microbiology*
Marine Biology
Molecular Sequence Data
Phylogeny
Symbiosis / physiology

Substances

Anti-Infective Agents
DNA, Ribosomal Spacer

Associated data

GENBANK/FJ618520
GENBANK/FJ618521
GENBANK/FJ618522