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MK3 modulation affects BMI1-dependent and independent cell cycle check-points.
Prickaerts P, Niessen HE, Dahlmans VE, Spaapen F, Salvaing J, Vanhove J, Geijselaers C, Bartels SJ, Partouns I, Neumann D, Speel EJ, Takihara Y, Wouters BG, Voncken JW. Prickaerts P, et al. PLoS One. 2015 Apr 8;10(4):e0118840. doi: 10.1371/journal.pone.0118840. eCollection 2015. PLoS One. 2015. PMID: 25853770 Free PMC article.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG. van den Beucken T, et al. Among authors: prickaerts p. Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203. Nat Commun. 2014. PMID: 25351418 Free PMC article.
MK3 controls Polycomb target gene expression via negative feedback on ERK.
Prickaerts P, Niessen HE, Mouchel-Vielh E, Dahlmans VE, van den Akker GG, Geijselaers C, Adriaens ME, Spaapen F, Takihara Y, Rapp UR, Peronnet F, Voncken JW. Prickaerts P, et al. Epigenetics Chromatin. 2012 Aug 7;5(1):12. doi: 10.1186/1756-8935-5-12. Epigenetics Chromatin. 2012. PMID: 22870894 Free PMC article.
Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.
Adriaens ME, Prickaerts P, Chan-Seng-Yue M, van den Beucken T, Dahlmans VEH, Eijssen LM, Beck T, Wouters BG, Voncken JW, Evelo CTA. Adriaens ME, et al. Among authors: prickaerts p. Epigenetics Chromatin. 2016 Nov 1;9:48. doi: 10.1186/s13072-016-0090-4. eCollection 2016. Epigenetics Chromatin. 2016. PMID: 27822313 Free PMC article.