Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization.
Saito MS, Lourenço AL, Dias LR, Freitas AC, Vitorino MI, Albuquerque MG, Rodrigues CR, Cabral LM, Dias EP, Castro HC, Satlher PC.
Saito MS, et al.
J Enzyme Inhib Med Chem. 2016 Dec;31(6):1591-601. doi: 10.3109/14756366.2016.1158712. Epub 2016 Mar 22.
J Enzyme Inhib Med Chem. 2016.
PMID: 27000933
The antiplatelet activity of each derivative was confirmed as 3a, 3b and 3 h significantly inhibited human platelet aggregation induced by arachidonic acid, with no detectable effect on clotting factors or healthy erythrocytes. ...
The antiplatelet activity of each derivative was confirmed as 3a, 3b and 3 h significantly inhibited human platelet aggregation induc …