Abstract
This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
Keywords:
NMR; Sideritis hyssopifolia; anti-inflammatory; ent-kaurane.
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification
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Diterpenes, Kaurane / pharmacology*
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Humans
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Models, Molecular
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Sideritis / chemistry*
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Spectrum Analysis
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Diterpenes, Kaurane
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Plant Extracts