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Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: knapstein pr. bioRxiv [Preprint]. 2023 Jul 16:2023.07.14.548550. doi: 10.1101/2023.07.14.548550. bioRxiv. 2023. PMID: 37502964 Free PMC article. Preprint.
Tranexamic Acid Attenuates the Progression of Posttraumatic Osteoarthritis in Mice.
Xie W, Jiang S, Donat A, Knapstein PR, Albertsen LC, Kokot JL, Erdmann C, Rolvien T, Frosch KH, Baranowsky A, Keller J. Xie W, et al. Among authors: knapstein pr. Am J Sports Med. 2024 Mar;52(3):766-778. doi: 10.1177/03635465231220855. Epub 2024 Feb 2. Am J Sports Med. 2024. PMID: 38305280 Free PMC article.
Increased β2-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: knapstein pr. Sci Transl Med. 2024 Apr 17;16(743):eadk9129. doi: 10.1126/scitranslmed.adk9129. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630849