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Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia.
Liu Y, Gao W, Yang J, Guo H, Zhang J, Ji Y. Liu Y, et al. Pathogens. 2021 Oct 28;10(11):1396. doi: 10.3390/pathogens10111396. Pathogens. 2021. PMID: 34832552 Free PMC article.
In this study, we found that the null mutation of coa significantly decreased the mortality of CA-MRSA 923; moreover, the single null mutation of saeRS and the double deletion of coa/saeRS abolished the virulence of CA-MRSA 923. ...Furthermore, we examined the impac …
In this study, we found that the null mutation of coa significantly decreased the mortality of CA-MRSA 923; moreover, the single null mutati …
The SaeRS Two-Component System Controls Survival of Staphylococcus aureus in Human Blood through Regulation of Coagulase.
Guo H, Hall JW, Yang J, Ji Y. Guo H, et al. Front Cell Infect Microbiol. 2017 May 29;7:204. doi: 10.3389/fcimb.2017.00204. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28611950 Free PMC article.
In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. ...We found coagulase complementation abolished the enhanced surv …
In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementat …
Inactivation of a two-component signal transduction system, SaeRS, eliminates adherence and attenuates virulence of Staphylococcus aureus.
Liang X, Yu C, Sun J, Liu H, Landwehr C, Holmes D, Ji Y. Liang X, et al. Infect Immun. 2006 Aug;74(8):4655-65. doi: 10.1128/IAI.00322-06. Infect Immun. 2006. PMID: 16861653 Free PMC article.
In this study, we identified the regulon of a two-component signal transduction system, SaeRS, and demonstrated that the SaeRS system is required for S. aureus to cause infection both in vitro and in vivo. ...Moreover, we found that inactivation of the SaeRS …
In this study, we identified the regulon of a two-component signal transduction system, SaeRS, and demonstrated that the SaeRS …
The novel transcriptional regulator SA1804 Is involved in mediating the invasion and cytotoxicity of Staphylococcus aureus.
Yang J, Liang X, Ji Y. Yang J, et al. Front Microbiol. 2015 Mar 9;6:174. doi: 10.3389/fmicb.2015.00174. eCollection 2015. Front Microbiol. 2015. PMID: 25806024 Free PMC article.
Previously, we conducted a transcriptomics study for identification of SaeRS regulon and found that inactivation of SaeRS dramatically enhances the transcription of a novel transcriptional regulator (SA1804). ...Moreover, the double deletions of sa1804 and saeRS …
Previously, we conducted a transcriptomics study for identification of SaeRS regulon and found that inactivation of SaeRS dram …
Comparative analysis of staphylococcal adhesion and internalization by epithelial cells.
Liang X, Ji Y. Liang X, et al. Methods Mol Biol. 2007;391:145-51. doi: 10.1007/978-1-59745-468-1_11. Methods Mol Biol. 2007. PMID: 18025675
We have shown that a two-component signal transduction system, SaeRS, is essential for bacterial adhesion and invasion of the epithelial cells....
We have shown that a two-component signal transduction system, SaeRS, is essential for bacterial adhesion and invasion of the epithel …