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Cellular metabolic pathways of aging in dogs: could p53 and SIRT1 be at play?
Jiménez AG, Paul KD, Benson M, Lalwani S, Cipolli W. Jiménez AG, et al. Among authors: paul kd. Geroscience. 2024 Apr;46(2):1895-1908. doi: 10.1007/s11357-023-00942-y. Epub 2023 Sep 28. Geroscience. 2024. PMID: 37768524 Free PMC article.
We demonstrate that, due to a higher p53 nuclear to cytoplasmic ratio in large breed dogs after UV treatment, p53 could have a more regulatory effect on large breed dogs' metabolism compared with smaller breeds. Thus, there may be a link between p53 upregulation and inhibi …
We demonstrate that, due to a higher p53 nuclear to cytoplasmic ratio in large breed dogs after UV treatment, p53 could have a more regulato …
A simple rule governs the evolution and development of hominin tooth size.
Evans AR, Daly ES, Catlett KK, Paul KS, King SJ, Skinner MM, Nesse HP, Hublin JJ, Townsend GC, Schwartz GT, Jernvall J. Evans AR, et al. Among authors: paul ks. Nature. 2016 Feb 25;530(7591):477-80. doi: 10.1038/nature16972. Nature. 2016. PMID: 26911784
However, in species of Homo, including modern humans, there is a tight link between tooth proportions and absolute size such that a single developmental parameter can explain both the relative and absolute sizes of primary postcanine teeth. ...
However, in species of Homo, including modern humans, there is a tight link between tooth proportions and absolute size such that a s …
Subunit organization and reversal-associated movements in the flagellar switch of Escherichia coli.
Sarkar MK, Paul K, Blair DF. Sarkar MK, et al. Among authors: paul k. J Biol Chem. 2010 Jan 1;285(1):675-84. doi: 10.1074/jbc.M109.068676. Epub 2009 Oct 26. J Biol Chem. 2010. PMID: 19858188 Free PMC article.
When motors were switched to clockwise rotation by a repellent stimulus, cross-link yields were altered in a pattern indicating relative movement of FliN and FliM(C). ...
When motors were switched to clockwise rotation by a repellent stimulus, cross-link yields were altered in a pattern indicating relat …
Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients.
Griese M, Essl R, Schmidt R, Ballmann M, Paul K, Rietschel E, Ratjen F; Beat Study Group. Griese M, et al. Among authors: paul k. Respir Res. 2005 Nov 7;6(1):133. doi: 10.1186/1465-9921-6-133. Respir Res. 2005. PMID: 16274485 Free PMC article. Clinical Trial.
The concentrations of the surfactant specific proteins A, C and D did not change, whereas SP-B increased during this time period. CONCLUSION: Our findings suggest a link between loss of surfactant function driven by progressive airway inflammation and loss of small airway …
The concentrations of the surfactant specific proteins A, C and D did not change, whereas SP-B increased during this time period. CONCLUSION …
Accumulation dynamics and acute toxicity of silver nanoparticles to Daphnia magna and Lumbriculus variegatus: implications for metal modeling approaches.
Khan FR, Paul KB, Dybowska AD, Valsami-Jones E, Lead JR, Stone V, Fernandes TF. Khan FR, et al. Among authors: paul kb. Environ Sci Technol. 2015 Apr 7;49(7):4389-97. doi: 10.1021/es506124x. Epub 2015 Mar 20. Environ Sci Technol. 2015. PMID: 25756614
., biotic ligand model (BLM) and tissue residue approach (TRA)) are based on the established link between uptake, accumulation and toxicity, but similar relationships remain unverified for metal-containing nanoparticles (NPs). ...
., biotic ligand model (BLM) and tissue residue approach (TRA)) are based on the established link between uptake, accumulation and to …
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study.
Kannarkat GT, Cook DA, Lee JK, Chang J, Chung J, Sandy E, Paul KC, Ritz B, Bronstein J, Factor SA, Boss JM, Tansey MG. Kannarkat GT, et al. Among authors: paul kc. NPJ Parkinsons Dis. 2015;1:15002-. doi: 10.1038/npjparkd.2015.2. Epub 2015 Apr 22. NPJ Parkinsons Dis. 2015. PMID: 27148593 Free PMC article.
The location of the SNP in the major histocompatibility complex class II (MHC-II) locus implicates regulation of antigen presentation as a potential mechanism by which immune responses link genetic susceptibility to environmental factors in conferring lifetime risk for PD. …
The location of the SNP in the major histocompatibility complex class II (MHC-II) locus implicates regulation of antigen presentation as a p …