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An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins.
Cary JW, Uka V, Han Z, Buyst D, Harris-Coward PY, Ehrlich KC, Wei Q, Bhatnagar D, Dowd PF, Martens SL, Calvo AM, Martins JC, Vanhaecke L, Coenye T, De Saeger S, Di Mavungu JD. Cary JW, et al. Among authors: harris coward py. Fungal Genet Biol. 2015 Aug;81:88-97. doi: 10.1016/j.fgb.2015.05.010. Epub 2015 Jun 4. Fungal Genet Biol. 2015. PMID: 26051490
Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment.
Cary JW, Harris-Coward PY, Ehrlich KC, Di Mavungu JD, Malysheva SV, De Saeger S, Dowd PF, Shantappa S, Martens SL, Calvo AM. Cary JW, et al. Among authors: harris coward py. Fungal Genet Biol. 2014 Mar;64:25-35. doi: 10.1016/j.fgb.2014.01.001. Epub 2014 Jan 9. Fungal Genet Biol. 2014. PMID: 24412484