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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
COVIDSurg Collaborative. COVIDSurg Collaborative. Lancet Oncol. 2021 Nov;22(11):1507-1517. doi: 10.1016/S1470-2045(21)00493-9. Epub 2021 Oct 5. Lancet Oncol. 2021. PMID: 34624250 Free PMC article. Clinical Trial.
Light restrictions were associated with a 0.6% non-operation rate (26 of 4521), moderate lockdowns with a 5.5% rate (201 of 3646; adjusted hazard ratio [HR] 0.81, 95% CI 0.77-0.84; p<0.0001), and full lockdowns with a 15.0% rate (1775 of 11 827; HR 0.51, 0.50-0.53; p
Light restrictions were associated with a 0.6% non-operation rate (26 of 4521), moderate lockdowns with a 5.5% rate (201 of 3646; adjusted h …
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study.
COVIDSurg Collaborative. COVIDSurg Collaborative. Colorectal Dis. 2022 Mar 14;24(6):708-26. doi: 10.1111/codi.16117. Online ahead of print. Colorectal Dis. 2022. PMID: 35286766 Free PMC article.

Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0

Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery …
Profiling the serum proteome during Schistosoma mansoni infection in the BALB/c mice: A focus on the altered lipid metabolism as a key modulator of host-parasite interactions.
Gonçalves-Silva G, Vieira LGMDS, Cosenza-Contreras M, Souza AFP, Costa DC, Castro-Borges W. Gonçalves-Silva G, et al. Front Immunol. 2022 Aug 31;13:955049. doi: 10.3389/fimmu.2022.955049. eCollection 2022. Front Immunol. 2022. PMID: 36119112 Free PMC article.
Inspection of the lipid profile from control and infected individuals demonstrated more pronounced and significant alterations in triglycerides, VLDL and HDL fractions (p<0,001), attesting for a disturbance in circulating lipid molecules, and suggesting a key role in ho …
Inspection of the lipid profile from control and infected individuals demonstrated more pronounced and significant alterations in triglyceri …
Evaluation of schistosomula crude antigen (SCA) as a diagnostic tool for Schistosoma mansoni in low endemic human population.
Oyeyemi OT, Corsini CA, Gonçalves G, de Castro Borges W, Grenfell RFQ. Oyeyemi OT, et al. Sci Rep. 2021 May 18;11(1):10530. doi: 10.1038/s41598-021-89929-3. Sci Rep. 2021. PMID: 34006964 Free PMC article.

The area under the ROC curve was 0.95 (AUC 0.95, CI 0.88-1.01, p < 0.0001). The sensitivity and specificity of SCA-ELISA and dot blots assays were 96.67% and 86.67% respectively. The human IgG-specific response against SCA was significantly higher in S. mansoni infected

The area under the ROC curve was 0.95 (AUC 0.95, CI 0.88-1.01, p < 0.0001). The sensitivity and specificity of SCA-ELISA and dot b

Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.
Anthony B, Mathieson W, de Castro-Borges W, Allen J. Anthony B, et al. Exp Parasitol. 2010 Apr;124(4):409-20. doi: 10.1016/j.exppara.2009.12.009. Epub 2010 Jan 4. Exp Parasitol. 2010. PMID: 20045695
HSC demonstrate significantly reduced expression of alpha-smooth muscle actin (p<0.001), connective tissue growth factor (p<0.01) and type I collagen (p<0.001) but significantly increased expression of peroxisome proliferator-activated receptor-gamma …
HSC demonstrate significantly reduced expression of alpha-smooth muscle actin (p<0.001), connective tissue growth factor (p
Chemical, physical, and biological attributes in soils affected by deposition of iron ore tailings from the Fundão Dam failure.
Silva AO, Guimarães AA, Lopez BDO, Zanchi CS, Vega CFP, Batista ÉR, de Souza Moreira FM, da Costa Souza FR, Pinto FA, Dos Santos JV, Carneiro JJ, Siqueira JO, Kemmelmeier K, Guilherme LRG, Rufini M, de Souza Dias Junior M, da Silva Aragão OO, de Castro Borges PH, de Oliveira-Longatti SM, Carneiro MAC. Silva AO, et al. Environ Monit Assess. 2021 Jul 3;193(8):462. doi: 10.1007/s10661-021-09234-4. Environ Monit Assess. 2021. PMID: 34216287
According to result, the deposition of tailings increased the pH and the soil available P, Cr, Fe, and Mn content and reduced organic matter. The physical and biological attributes were negatively affected, with increases in the silt content and density of the soil, and re …
According to result, the deposition of tailings increased the pH and the soil available P, Cr, Fe, and Mn content and reduced organic …