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Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin.
Vaara M, Siikanen O, Apajalahti J, Frimodt-Møller N, Vaara T. Vaara M, et al. Among authors: siikanen o. J Antimicrob Chemother. 2010 May;65(5):942-5. doi: 10.1093/jac/dkq040. Epub 2010 Feb 18. J Antimicrob Chemother. 2010. PMID: 20167589
A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane.
Vaara M, Siikanen O, Apajalahti J, Fox J, Frimodt-Møller N, He H, Poudyal A, Li J, Nation RL, Vaara T. Vaara M, et al. Among authors: siikanen o. Antimicrob Agents Chemother. 2010 Aug;54(8):3341-6. doi: 10.1128/AAC.01439-09. Epub 2010 May 17. Antimicrob Agents Chemother. 2010. PMID: 20479195 Free PMC article.