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Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling.
Estupiñán Ó, Rey V, Tornín J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria González M, Rodríguez A, Moris F, González J, Ayllón V, Ramos-Mejía V, Bigas A, Rodríguez R. Estupiñán Ó, et al. Biomed Pharmacother. 2023 Jun;162:114627. doi: 10.1016/j.biopha.2023.114627. Epub 2023 Apr 3. Biomed Pharmacother. 2023. PMID: 37018985 Free article.
Proof of concept for the use of trained sniffer dogs to detect osteosarcoma.
Ortal A, Rodríguez A, Solis-Hernández MP, de Prado M, Rey V, Tornín J, Estupiñán Ó, Gallego B, Murillo D, Huergo C, García-Llano JL, Costilla S, Rodríguez R. Ortal A, et al. Among authors: estupinan o. Sci Rep. 2022 Apr 28;12(1):6911. doi: 10.1038/s41598-022-11013-1. Sci Rep. 2022. PMID: 35484295 Free PMC article.
Mithramycin delivery systems to develop effective therapies in sarcomas.
Estupiñán Ó, Niza E, Bravo I, Rey V, Tornín J, Gallego B, Clemente-Casares P, Moris F, Ocaña A, Blanco-Lorenzo V, Rodríguez-Santamaría M, Vallina-Álvarez A, González MV, Rodríguez A, Hermida-Merino D, Alonso-Moreno C, Rodríguez R. Estupiñán Ó, et al. J Nanobiotechnology. 2021 Sep 6;19(1):267. doi: 10.1186/s12951-021-01008-x. J Nanobiotechnology. 2021. PMID: 34488783 Free PMC article.
FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway.
Tornin J, Hermida-Prado F, Padda RS, Gonzalez MV, Alvarez-Fernandez C, Rey V, Martinez-Cruzado L, Estupiñan O, Menendez ST, Fernandez-Nevado L, Astudillo A, Rodrigo JP, Lucien F, Kim Y, Leong HS, Garcia-Pedrero JM, Rodriguez R. Tornin J, et al. Among authors: estupinan o. Neoplasia. 2018 Jan;20(1):44-56. doi: 10.1016/j.neo.2017.11.004. Epub 2017 Nov 28. Neoplasia. 2018. PMID: 29190494 Free PMC article.
The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas.
Estupiñan O, Santos L, Rodriguez A, Fernandez-Nevado L, Costales P, Perez-Escuredo J, Hermosilla MA, Oro P, Rey V, Tornin J, Allonca E, Fernandez-Garcia MT, Alvarez-Fernandez C, Braña A, Astudillo A, Menendez ST, Moris F, Rodriguez R. Estupiñan O, et al. Int J Cancer. 2019 Jul 1;145(1):254-266. doi: 10.1002/ijc.32081. Epub 2019 Jan 14. Int J Cancer. 2019. PMID: 30575954 Free article.
SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications.
Menendez ST, Rey V, Martinez-Cruzado L, Gonzalez MV, Morales-Molina A, Santos L, Blanco V, Alvarez C, Estupiñan O, Allonca E, Rodrigo JP, García-Castro J, Garcia-Pedrero JM, Rodriguez R. Menendez ST, et al. Among authors: estupinan o. Cancers (Basel). 2020 Apr 13;12(4):964. doi: 10.3390/cancers12040964. Cancers (Basel). 2020. PMID: 32295077 Free PMC article.