Reincarnation of the Analytical Ultracentrifuge: Emerging Opportunities for Nanomedicine

Anal Chem. 2021 Dec 7;93(48):15805-15815. doi: 10.1021/acs.analchem.1c03116. Epub 2021 Nov 21.

Abstract

The analytical ultracentrifuge (AUC) and the modern field of analytical ultracentrifugation found its inception approximately a century ago. We highlight the scope of its major experimental opportunities as a transport-based method, contemporary and up-and-coming investigation potential for polymers, polymer-drug conjugates, polymer assemblies, as well as medical nanoparticles. Special focus lies on molar mass estimates of unimeric polymeric species, self-assemblies in solution, and (co)localization of multicomponent systems in solution alongside the material-biofluid interactions. We close with present challenges and incentives for future research.

Publication types

  • News
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Weight
  • Nanomedicine*
  • Nanoparticles*
  • Polymers
  • Ultracentrifugation

Substances

  • Polymers