Functional analysis of monoclonal antibodies against the Plasmodium falciparum PfEMP1-VarO adhesin.
Guillotte M, Nato F, Juillerat A, Hessel A, Marchand F, Lewit-Bentley A, Bentley GA, Vigan-Womas I, Mercereau-Puijalon O.
Guillotte M, et al.
Malar J. 2016 Jan 15;15:28. doi: 10.1186/s12936-015-1016-5.
Malar J. 2016.
PMID: 26772184
Free PMC article.
Based on competition ELISA and binding to mutant DBL1 domains, two distinct binding sites for rosette-disrupting mAbs were identified in close proximity to the RBC-binding site. CONCLUSIONS: Rosette-inhibitory antibodies bind to conformation-dependent epitopes located c …
Based on competition ELISA and binding to mutant DBL1 domains, two distinct binding sites for rosette-disrupting mAbs were identified in …