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2007 1
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Page 1
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE. Lawlor KE, et al. Among authors: khan n. Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282. Nat Commun. 2015. PMID: 25693118 Free PMC article.
IAPS and ubiquitylation.
Feltham R, Khan N, Silke J. Feltham R, et al. Among authors: khan n. IUBMB Life. 2012 May;64(5):411-8. doi: 10.1002/iub.565. Epub 2012 Feb 23. IUBMB Life. 2012. PMID: 22362579 Free article. Review.
Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.
Tanzer MC, Khan N, Rickard JA, Etemadi N, Lalaoui N, Spall SK, Hildebrand JM, Segal D, Miasari M, Chau D, Wong WL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vince JE, Herold MJ, Silke J. Tanzer MC, et al. Among authors: khan n. Cell Death Differ. 2017 Mar;24(3):481-491. doi: 10.1038/cdd.2016.147. Epub 2017 Jan 20. Cell Death Differ. 2017. PMID: 28106882 Free PMC article.
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. Vince JE, et al. Among authors: khan n. Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037. Cell. 2007. PMID: 18022363 Free article.
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.
Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK. Condon SM, et al. Among authors: khan n. J Med Chem. 2014 May 8;57(9):3666-77. doi: 10.1021/jm500176w. Epub 2014 Apr 15. J Med Chem. 2014. PMID: 24684347
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: khan nr. J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339290 Free PMC article.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: khan nr. J Biol Chem. 2016 Jan 29;291(5):2547. doi: 10.1074/jbc.A110.216226. J Biol Chem. 2016. PMID: 26826208 Free PMC article. No abstract available.