Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1952 3
1959 1
1966 3
1967 2
1968 3
1970 1
1971 2
1973 1
1976 2
1978 1
1981 1
1982 1
1983 2
1984 1
1985 2
1986 1
1987 2
1989 2
1990 1
1991 4
1992 2
1993 3
1994 6
1995 11
1996 18
1997 20
1998 16
1999 19
2000 21
2001 9
2002 12
2003 7
2004 14
2005 12
2006 9
2007 12
2008 17
2009 9
2010 9
2011 11
2012 8
2013 12
2014 13
2015 5
2016 7
2017 8
2018 9
2019 16
2020 21
2021 13
2022 15
2023 13
2024 7

Text availability

Article attribute

Article type

Publication date

Search Results

396 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for normal topo
Your search for Normam Toro retrieved no results
Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Shao Z, Lee BJ, Zhang H, Lin X, Li C, Jiang W, Chirathivat N, Gershik S, Shen MM, Baer R, Zha S. Shao Z, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2301972120. doi: 10.1073/pnas.2301972120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487079 Free PMC article.
PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability. Here we show that, in contrast to the normal development of Parp1-null mice, heterozygous expression of catalytically inactive Parp1 (E988A, Parp1( …
PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability. Here we show t …
Expressions of Topo IIalpha and Ki67 in breast cancer and its clinicopathologic features and prognosis.
Sun G, Wang S, Wang Y. Sun G, et al. Pak J Med Sci. 2019;35(3):715-720. doi: 10.12669/pjms.35.3.81. Pak J Med Sci. 2019. PMID: 31258582 Free PMC article.
Ki67 and Topo IIalpha in the breast cancer tissues and normal breast tissues were detected using immunohistochemical method. ...RESULTS: It was found that the positive expressions of Ki67 and Topo IIalpha in the breast cancer tissues were higher than those in …
Ki67 and Topo IIalpha in the breast cancer tissues and normal breast tissues were detected using immunohistochemical method. . …
Structure and Chromosomal Organization of Yeast Genes Regulated by Topoisomerase II.
Joshi RS, Nikolaou C, Roca J. Joshi RS, et al. Int J Mol Sci. 2018 Jan 3;19(1):134. doi: 10.3390/ijms19010134. Int J Mol Sci. 2018. PMID: 29301361 Free PMC article. Review.
Cellular DNA topoisomerases (topo I and topo II) are highly conserved enzymes that regulate the topology of DNA during normal genome transactions, such as DNA transcription and replication. In budding yeast, topo I is dispensable whereas topo II …
Cellular DNA topoisomerases (topo I and topo II) are highly conserved enzymes that regulate the topology of DNA during norm …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies.
Khalifa MM, Al-Karmalawy AA, Elkaeed EB, Nafie MS, Tantawy MA, Eissa IH, Mahdy HA. Khalifa MM, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):299-314. doi: 10.1080/14756366.2021.2007905. J Enzyme Inhib Med Chem. 2022. PMID: 34894955 Free PMC article.
Topo II inhibition and DNA intercalating activities were evaluated for the most cytotoxic members. IC(50) values determination demonstrated Topo II inhibitory activities and DNA intercalating affinities of the tested compounds at a micromolar level. ...
Topo II inhibition and DNA intercalating activities were evaluated for the most cytotoxic members. IC(50) values determination demons …
The current status of camptothecin analogues as antitumor agents.
Slichenmyer WJ, Rowinsky EK, Donehower RC, Kaufmann SH. Slichenmyer WJ, et al. J Natl Cancer Inst. 1993 Feb 17;85(4):271-91. doi: 10.1093/jnci/85.4.271. J Natl Cancer Inst. 1993. PMID: 8381186 Review.
In normal cells, topo I is thought to be involved in gene transcription and DNA replication. During the course of its normal catalytic cycle, topo I transiently forms a covalent bond with DNA. ...
In normal cells, topo I is thought to be involved in gene transcription and DNA replication. During the course of its norma …
Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs.
Zhao M, Yang K, Zhu X, Gao T, Yu W, Liu H, You Z, Liu Z, Qiao X, Song Y. Zhao M, et al. Eur J Med Chem. 2023 Apr 5;252:115303. doi: 10.1016/j.ejmech.2023.115303. Epub 2023 Mar 24. Eur J Med Chem. 2023. PMID: 36996717
Both topoisomerase II (Topo II) and histone deacetylase (HDAC) are important therapeutic targets for cancer. ...In the enzyme activity inhibition experiments, compounds 7d and 8d exhibited excellent dual inhibitory activities against Topo II and HDAC. Cleavage react …
Both topoisomerase II (Topo II) and histone deacetylase (HDAC) are important therapeutic targets for cancer. ...In the enzyme activit …
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.
Lee JH, Mosher EP, Lee YS, Bumpus NN, Berger JM. Lee JH, et al. Cell Chem Biol. 2022 Mar 17;29(3):476-489.e6. doi: 10.1016/j.chembiol.2021.08.014. Epub 2021 Sep 15. Cell Chem Biol. 2022. PMID: 34529934 Free PMC article.
Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the physical passage of one duplex through another and depends on the transient formation of double-stranded DNA breaks, a step exploited by frontline chemotherap …
Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the physical passage o …
Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors.
Kadagathur M, Sujat Shaikh A, Panda B, George J, Phanindranath R, Kumar Sigalapalli D, Bhale NA, Godugu C, Nagesh N, Shankaraiah N, Tangellamudi ND. Kadagathur M, et al. Bioorg Chem. 2022 May;122:105706. doi: 10.1016/j.bioorg.2022.105706. Epub 2022 Feb 25. Bioorg Chem. 2022. PMID: 35240414

Among the synthesized molecules (14a-m and 15a-d), compound 14d displayed remarkable activity against A549, HCT116 and SK-MEL-28 cells with IC(50) values < 4 muM with the best cytotoxicity and a 13-fold selectivity towards lung cancer cells (IC(50) value of 2.33 muM) over the

…
Among the synthesized molecules (14a-m and 15a-d), compound 14d displayed remarkable activity against A549, HCT116 and SK-MEL-28 cells with …
Clinical resistance to topoisomerase-targeted drugs.
Dingemans AM, Pinedo HM, Giaccone G. Dingemans AM, et al. Biochim Biophys Acta. 1998 Oct 1;1400(1-3):275-88. doi: 10.1016/s0167-4781(98)00141-9. Biochim Biophys Acta. 1998. PMID: 9748627 Review.
This review describes topoisomerase (topo)-mediated drug resistance and topo expression in human tissues and cancers. ...Furthermore, higher topo I levels were observed in some tumors when compared to their normal counterparts. ...
This review describes topoisomerase (topo)-mediated drug resistance and topo expression in human tissues and cancers. ...Furth …
Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.
Mirski SE, Voskoglou-Nomikos T, Young LC, Deeley RG, Campling BG, Gerlach JH, Cole SP. Mirski SE, et al. Lab Invest. 2000 Jun;80(6):787-95. doi: 10.1038/labinvest.3780083. Lab Invest. 2000. PMID: 10879730 Free article.
In contrast, topo IIbeta mRNA levels were similar in both tumor and normal lung. ...Topo IIbeta mRNA levels in the squamous cell tumors were also significantly lower than those in paired normal lung tissue. ...
In contrast, topo IIbeta mRNA levels were similar in both tumor and normal lung. ...Topo IIbeta mRNA levels in the squa …
396 results