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The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.
Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtimäki TE, Seppänen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-Järvinen H. Luukkonen PK, et al. Among authors: ahlholm n. Cell Metab. 2023 Nov 7;35(11):1887-1896.e5. doi: 10.1016/j.cmet.2023.10.008. Epub 2023 Oct 30. Cell Metab. 2023. PMID: 37909034 Free article.
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease.
Luukkonen PK, Qadri S, Ahlholm N, Porthan K, Männistö V, Sammalkorpi H, Penttilä AK, Hakkarainen A, Lehtimäki TE, Gaggini M, Gastaldelli A, Ala-Korpela M, Orho-Melander M, Arola J, Juuti A, Pihlajamäki J, Hodson L, Yki-Järvinen H. Luukkonen PK, et al. Among authors: ahlholm n. J Hepatol. 2022 Mar;76(3):526-535. doi: 10.1016/j.jhep.2021.10.013. Epub 2021 Oct 25. J Hepatol. 2022. PMID: 34710482 Free PMC article.
Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease.
Tamaki N, Ahlholm N, Luukkonen PK, Porthan K, Sharpton SR, Ajmera V, Kono Y, Dave S, Ahmed A, Sundaram V, Wilkinson MJ, Patton H, Gupta H, Cervantes V, Hernandez C, Lopez SJ, Loomba R, Baumgartner A, Richards L, Arkkila PE, Nemes K, Isoniemi H, Yki-Järvinen H, Loomba R. Tamaki N, et al. Among authors: ahlholm n. J Clin Invest. 2022 Nov 1;132(21):e162513. doi: 10.1172/JCI162513. J Clin Invest. 2022. PMID: 36317632 Free PMC article.
Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study.
Huang DQ, Ahlholm N, Luukkonen PK, Porthan K, Amangurbanova M, Madamba E, Bettencourt R, Siddiqi H, Cervantes V, Hernandez C, Lopez SJ, Richards L, Nemes K, Isoniemi H, Yki-Järvinen H, Loomba R. Huang DQ, et al. Among authors: ahlholm n. Clin Gastroenterol Hepatol. 2024 Jan;22(1):81-90.e4. doi: 10.1016/j.cgh.2023.06.020. Epub 2023 Jul 3. Clin Gastroenterol Hepatol. 2024. PMID: 37406954 Free article.
Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease.
Qadri S, Ahlholm N, Lønsmann I, Pellegrini P, Poikola A, Luukkonen PK, Porthan K, Juuti A, Sammalkorpi H, Penttilä AK, D'Ambrosio R, Soardo G, Leeming DJ, Karsdal M, Arola J, Kechagias S, Pelusi S, Ekstedt M, Valenti L, Hagström H, Yki-Järvinen H. Qadri S, et al. Among authors: ahlholm n. J Clin Endocrinol Metab. 2022 Apr 19;107(5):e2008-e2020. doi: 10.1210/clinem/dgab933. J Clin Endocrinol Metab. 2022. PMID: 34971370 Free PMC article.
The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles.
Lahelma M, Qadri S, Ahlholm N, Porthan K, Ruuth M, Juuti A, Orešič M, Hyötyläinen T, Öörni K, Yki-Järvinen H. Lahelma M, et al. Among authors: ahlholm n. Atherosclerosis. 2022 Dec;363:22-29. doi: 10.1016/j.atherosclerosis.2022.11.018. Epub 2022 Nov 23. Atherosclerosis. 2022. PMID: 36455305 Free article.