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Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets.
Mthembu SXH, Mazibuko-Mbeje SE, Ziqubu K, Nyawo TA, Obonye N, Nyambuya TM, Nkambule BB, Silvestri S, Tiano L, Muller CJF, Dludla PV. Mthembu SXH, et al. Among authors: obonye n. Life Sci. 2022 May 15;297:120467. doi: 10.1016/j.lfs.2022.120467. Epub 2022 Mar 7. Life Sci. 2022. PMID: 35271881 Review.
N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q9/10 levels.
Dludla PV, Orlando P, Silvestri S, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F, Cirilli I, Muller CJF, Louw J, Obonye N, Nyawo T, Nkambule BB, Tiano L. Dludla PV, et al. Among authors: obonye n. Toxicol Rep. 2019 Nov 5;6:1240-1245. doi: 10.1016/j.toxrep.2019.11.004. eCollection 2019. Toxicol Rep. 2019. PMID: 31799124 Free PMC article.
Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10.
Dludla PV, Silvestri S, Orlando P, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F, Cirilli I, Muller CJF, Louw J, Chellan N, Obonye N, Nkambule BB, Tiano L. Dludla PV, et al. Among authors: obonye n. Toxicol In Vitro. 2020 Oct;68:104948. doi: 10.1016/j.tiv.2020.104948. Epub 2020 Jul 16. Toxicol In Vitro. 2020. PMID: 32683093