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Showing results for ndna repair
Your search for Nina Repar retrieved no results
Analysis of mtDNA/nDNA Ratio in Mice.
Quiros PM, Goyal A, Jha P, Auwerx J. Quiros PM, et al. Curr Protoc Mouse Biol. 2017 Mar 2;7(1):47-54. doi: 10.1002/cpmo.21. Curr Protoc Mouse Biol. 2017. PMID: 28252199 Free PMC article.
Mitochondrial DNA (mtDNA) lacks the protection provided by the nucleosomes in the nuclear DNA and does not have a DNA repair mechanism, making it highly susceptible to damage, which can lead to mtDNA depletion. mtDNA depletion compromises the efficient function of cells an …
Mitochondrial DNA (mtDNA) lacks the protection provided by the nucleosomes in the nuclear DNA and does not have a DNA repair mechanis …
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Wu Z, et al. Nat Metab. 2019 Dec;1(12):1209-1218. doi: 10.1038/s42255-019-0150-8. Epub 2019 Dec 9. Nat Metab. 2019. PMID: 32395698 Free PMC article.
Instead, a specific subset of ISGs, that includes Parp9, remains activated by the unphosphorylated form of ISGF3 (U-ISGF3) that enhances nDNA damage and repair responses. In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes …
Instead, a specific subset of ISGs, that includes Parp9, remains activated by the unphosphorylated form of ISGF3 (U-ISGF3) that enhances …
Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy.
Ashraf S, Deshpande N, Vasanth S, Melangath G, Wong RJ, Zhao Y, Price MO, Price FW Jr, Jurkunas UV. Ashraf S, et al. Exp Eye Res. 2023 Jun;231:109499. doi: 10.1016/j.exer.2023.109499. Epub 2023 May 9. Exp Eye Res. 2023. PMID: 37169279
FECD specimens exhibited downregulation of 9 genes and upregulation of 8 genes belonging to the four major DNA repair pathways, namely, base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), and double strand break (DSB) …
FECD specimens exhibited downregulation of 9 genes and upregulation of 8 genes belonging to the four major DNA repair pathways, namel …
Mitochondrial disorders.
Kanungo S, Morton J, Neelakantan M, Ching K, Saeedian J, Goldstein A. Kanungo S, et al. Ann Transl Med. 2018 Dec;6(24):475. doi: 10.21037/atm.2018.12.13. Ann Transl Med. 2018. PMID: 30740406 Free PMC article. Review.
Additional nuclear (n)DNA encoded genes maintain mitochondrial biogenesis by supervising mtDNA replication, repair and synthesis, which is modified during increased energy demands or physiological stress. ...
Additional nuclear (n)DNA encoded genes maintain mitochondrial biogenesis by supervising mtDNA replication, repair and synthesis, whi …
Nuclear and mitochondrial DNA repair: similar pathways?
Larsen NB, Rasmussen M, Rasmussen LJ. Larsen NB, et al. Mitochondrion. 2005 Apr;5(2):89-108. doi: 10.1016/j.mito.2005.02.002. Mitochondrion. 2005. PMID: 16050976 Review.
Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases and alterations of the mitochondrial genome are assumed to be a result of its high susceptibility to oxidative damage and its limited DNA repair compared to nuclear DNA (nDNA). C …
Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases and alterations of the mitochondrial genome are assu …
Ribonucleotides in mitochondrial DNA.
Wanrooij PH, Chabes A. Wanrooij PH, et al. FEBS Lett. 2019 Jul;593(13):1554-1565. doi: 10.1002/1873-3468.13440. Epub 2019 May 24. FEBS Lett. 2019. PMID: 31093968 Free article. Review.
Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP content. This is largely due to differences in rNMP repair - whereas rNMPs are efficiently removed from the nucle …
Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with r …
Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells.
Zhao X, Wang C, Dai S, Liu Y, Zhang F, Peng C, Li Y. Zhao X, et al. Oxid Med Cell Longev. 2022 Jul 16;2022:4591134. doi: 10.1155/2022/4591134. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35879991 Free PMC article.
Mitochondrial dynamics (Mito Tracker Green), mitROS (MitoSOX Red Mitochondrial Superoxide) production, and nuclear DNA (nDNA) damage (gammaH2AX) markers were detected by immunofluorescence. ...The results showed that quercetin treatment downregulated redox status, lipid dr …
Mitochondrial dynamics (Mito Tracker Green), mitROS (MitoSOX Red Mitochondrial Superoxide) production, and nuclear DNA (nDNA) damage …
Mitochondrial diseases in adults.
La Morgia C, Maresca A, Caporali L, Valentino ML, Carelli V. La Morgia C, et al. J Intern Med. 2020 Jun;287(6):592-608. doi: 10.1111/joim.13064. J Intern Med. 2020. PMID: 32463135 Free article. Review.
In fact, in addition to the about 1.500 genes encoding mitochondrial proteins that reside in the nuclear genome (nDNA), we have the 13 proteins encoded by the mitochondrial genome (mtDNA), for which 22 specific tRNAs and 2 rRNAs are also needed. ...
In fact, in addition to the about 1.500 genes encoding mitochondrial proteins that reside in the nuclear genome (nDNA), we have the 1 …
DNA damage and repair in age-related macular degeneration.
Blasiak J, Szaflik JP. Blasiak J, et al. Front Biosci (Landmark Ed). 2011 Jan 1;16(4):1291-301. doi: 10.2741/3789. Front Biosci (Landmark Ed). 2011. PMID: 21196232 Free article.
However, the metabolism of mtDNA is mainly determined by the expression of nDNA. Therefore, the extent of damage to mtDNA in retinal cells depends on the overall efficacy of nDNA repair, which decreases with age. We showed an association between nDNA d …
However, the metabolism of mtDNA is mainly determined by the expression of nDNA. Therefore, the extent of damage to mtDNA in retinal …
Nuclear DNA damage as a direct cause of aging.
Best BP. Best BP. Rejuvenation Res. 2009 Jun;12(3):199-208. doi: 10.1089/rej.2009.0847. Rejuvenation Res. 2009. PMID: 19594328 Review.
Many studies show significant nDNA damage with age, associated with declining nDNA repair, and this evidence for the decline of nDNA repair with age is also reviewed. Mammalian lifespans correlate with the effectiveness of nDNA repair …
Many studies show significant nDNA damage with age, associated with declining nDNA repair, and this evidence for the de …
88 results