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1981 4
1982 1
1984 3
1985 3
1988 3
1989 3
1990 3
1991 8
1992 8
1993 4
1994 8
1995 7
1996 6
1997 11
1998 29
1999 32
2000 44
2001 50
2002 40
2003 50
2004 48
2005 51
2006 49
2007 55
2008 55
2009 52
2010 69
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1,569 results

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The following term was not found in PubMed: Nurnaeimah
Page 1
Non-canonical NF-κB signaling pathway.
Sun SC. Sun SC. Cell Res. 2011 Jan;21(1):71-85. doi: 10.1038/cr.2010.177. Epub 2010 Dec 21. Cell Res. 2011. PMID: 21173796 Free PMC article. Review.
A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destruction complex and signal-induced non-canonical NF-kappaB signaling involves NIK stabilization. Tight control of the fate of NIK is …
A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destructio …
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
Zhang Z, Zhong X, Shen H, Sheng L, Liangpunsakul S, Lok AS, Omary MB, Wang S, Rui L. Zhang Z, et al. Nat Commun. 2022 Aug 30;13(1):5111. doi: 10.1038/s41467-022-32575-8. Nat Commun. 2022. PMID: 36042192 Free PMC article.
DDC, ANIT, or BDL induces ductular reaction, liver injury, inflammation, and fibrosis in mice. Cholangiocyte-specific deletion of NIK, but not IKKalpha, blunts these pathological alterations. NIK inhibitor treatment similarly ameliorates DDC-induced ductular reactio …
DDC, ANIT, or BDL induces ductular reaction, liver injury, inflammation, and fibrosis in mice. Cholangiocyte-specific deletion of NIK …
EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, Kir S. Bilgic SN, et al. Nature. 2023 May;617(7962):827-834. doi: 10.1038/s41586-023-06047-y. Epub 2023 May 10. Nature. 2023. PMID: 37165186
EDA-A2-driven myotube atrophy involved activation of the non-canonical NFqB pathway and was dependent on NFkappaB-inducing kinase (NIK) activity. Whereas EDA-A2 overexpression promoted muscle wasting in mice, deletion of either EDA2R or muscle NIK protected tumour-b …
EDA-A2-driven myotube atrophy involved activation of the non-canonical NFqB pathway and was dependent on NFkappaB-inducing kinase (NIK …
NFkB Pathway and Hodgkin Lymphoma.
Jardin F. Jardin F. Biomedicines. 2022 Sep 1;10(9):2153. doi: 10.3390/biomedicines10092153. Biomedicines. 2022. PMID: 36140254 Free PMC article. Review.
Therefore, NFkB target genes are involved in apoptosis, cell proliferation, JAK/STAT pathway activation, B-cell marker expression loss, cellular interaction and a positive NFkB feedback loop. Targeting this complex pathway directly (NIK inhibitors) or indirectly (PIM, BTK …
Therefore, NFkB target genes are involved in apoptosis, cell proliferation, JAK/STAT pathway activation, B-cell marker expression loss, cell …
The noncanonical NF-κB pathway.
Sun SC. Sun SC. Immunol Rev. 2012 Mar;246(1):125-40. doi: 10.1111/j.1600-065X.2011.01088.x. Immunol Rev. 2012. PMID: 22435551 Free PMC article. Review.
Under normal conditions, NIK is targeted for continuous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TRAF3)-dependent E3 ubiquitin ligase. In response to signals mediated by a subset of TNF receptor superfamily members, NIK becomes stab …
Under normal conditions, NIK is targeted for continuous degradation by a tumor necrosis factor (TNF) receptor-associated factor-3 (TR …
NIK as a Druggable Mediator of Tissue Injury.
Valiño-Rivas L, Vaquero JJ, Sucunza D, Gutierrez S, Sanz AB, Fresno M, Ortiz A, Sanchez-Niño MD. Valiño-Rivas L, et al. Trends Mol Med. 2019 Apr;25(4):341-360. doi: 10.1016/j.molmed.2019.02.005. Epub 2019 Mar 26. Trends Mol Med. 2019. PMID: 30926358 Review.
The spectrum of NIK-associated disease now ranges from immunodeficiency (when NIK is defective) to autoimmunity, cancer, sterile inflammation, fibrosis, and metabolic disease when NIK is overactive. The development of novel small-molecule NIK inhibitor …
The spectrum of NIK-associated disease now ranges from immunodeficiency (when NIK is defective) to autoimmunity, cancer, steri …
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT. Vesting AJ, et al. Mol Metab. 2022 Dec;66:101626. doi: 10.1016/j.molmet.2022.101626. Epub 2022 Nov 7. Mol Metab. 2022. PMID: 36356831 Free PMC article.
METHODS: Here, we investigated non-canonical NFkappaB-inducing kinase (NIK/MAP3K14) in metabolic NASH, NASH to HCC transition, and DEN-induced HCC. ...Instead, hepatic NIK attenuated hepatoprotective JAK2/STAT5 signaling that is a prerequisite for NASH and NASH to H …
METHODS: Here, we investigated non-canonical NFkappaB-inducing kinase (NIK/MAP3K14) in metabolic NASH, NASH to HCC transition, and DE …
NF-kappaB-inducing kinase in cancer.
Maubach G, Feige MH, Lim MCC, Naumann M. Maubach G, et al. Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):40-49. doi: 10.1016/j.bbcan.2018.10.002. Epub 2018 Nov 9. Biochim Biophys Acta Rev Cancer. 2019. PMID: 30419317 Review.
Pivotal for the activation of the alternative NF-kappaB pathway is the stabilization of the NF-kappaB-inducing kinase (NIK). The aim of this review is to focus on the emerging role of NIK in cancer. The documented subversion of NIK in cancers highlights NI …
Pivotal for the activation of the alternative NF-kappaB pathway is the stabilization of the NF-kappaB-inducing kinase (NIK). The aim …
The Therapeutic Potential of Targeting NIK in B Cell Malignancies.
Haselager MV, Eldering E. Haselager MV, et al. Front Immunol. 2022 Jul 12;13:930986. doi: 10.3389/fimmu.2022.930986. eCollection 2022. Front Immunol. 2022. PMID: 35911754 Free PMC article. Review.
However, disease-specific in vitro and in vivo studies investigating NIK inhibition are as of yet lacking, and clinical trials with NIK inhibitors remain to be initiated. In order to bridge the gap between bench and bedside, this review first briefly summarizes our …
However, disease-specific in vitro and in vivo studies investigating NIK inhibition are as of yet lacking, and clinical trials with …
Targeting NF-kappaB-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer.
Pflug KM, Sitcheran R. Pflug KM, et al. Int J Mol Sci. 2020 Nov 11;21(22):8470. doi: 10.3390/ijms21228470. Int J Mol Sci. 2020. PMID: 33187137 Free PMC article. Review.
As such aberrant expression or regulation of NIK is associated with several disease states. For example, loss of NIK leads to severe immune defects, while the overexpression of NIK is observed in inflammatory diseases, metabolic disorders, and the development …
As such aberrant expression or regulation of NIK is associated with several disease states. For example, loss of NIK leads to …
1,569 results