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Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors.
Zhang L, Wei F, Borrego D, Zhao F, Río JMD, Frutos-Beltrán E, Zhang J, Xu S, López-Carrobles N, Gao S, Kang D, Pannecouque C, Clercq E, Liu X, Menéndez-Arias L, Zhan P. Zhang L, et al. Among authors: lopez carrobles n. Eur J Med Chem. 2022 Oct 5;240:114563. doi: 10.1016/j.ejmech.2022.114563. Epub 2022 Jun 26. Eur J Med Chem. 2022. PMID: 35780636
Charge Engineering of the Nucleic Acid Binding Cleft of a Thermostable HIV-1 Reverse Transcriptase Reveals Key Interactions and a Novel Mechanism of RNase H Inactivation.
Martínez Del Río J, López-Carrobles N, Mendieta-Moreno JI, Herrera-Chacón Ó, Sánchez-Ibáñez A, Mendieta J, Menéndez-Arias L. Martínez Del Río J, et al. Among authors: lopez carrobles n. J Mol Biol. 2023 Sep 15;435(18):168219. doi: 10.1016/j.jmb.2023.168219. Epub 2023 Aug 1. J Mol Biol. 2023. PMID: 37536391 Free article.
Enzyme-support interactions and inactivation conditions determine Thermomyces lanuginosus lipase inactivation pathways: Functional and florescence studies.
Souza PMP, Carballares D, Lopez-Carrobles N, Gonçalves LRB, Lopez-Gallego F, Rodrigues S, Fernandez-Lafuente R. Souza PMP, et al. Among authors: lopez carrobles n. Int J Biol Macromol. 2021 Nov 30;191:79-91. doi: 10.1016/j.ijbiomac.2021.09.061. Epub 2021 Sep 16. Int J Biol Macromol. 2021. PMID: 34537296 Free article.
Effect of protein load on stability of immobilized enzymes.
Fernandez-Lopez L, Pedrero SG, Lopez-Carrobles N, Gorines BC, Virgen-Ortíz JJ, Fernandez-Lafuente R. Fernandez-Lopez L, et al. Among authors: lopez carrobles n. Enzyme Microb Technol. 2017 Mar;98:18-25. doi: 10.1016/j.enzmictec.2016.12.002. Epub 2016 Dec 16. Enzyme Microb Technol. 2017. PMID: 28110660
Desorption of Lipases Immobilized on Octyl-Agarose Beads and Coated with Ionic Polymers after Thermal Inactivation. Stronger Adsorption of Polymers/Unfolded Protein Composites.
Virgen-Ortíz JJ, Pedrero SG, Fernandez-Lopez L, Lopez-Carrobles N, Gorines BC, Otero C, Fernandez-Lafuente R. Virgen-Ortíz JJ, et al. Among authors: lopez carrobles n. Molecules. 2017 Jan 5;22(1):91. doi: 10.3390/molecules22010091. Molecules. 2017. PMID: 28067789 Free PMC article.