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Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT).
van Haren MJ, Zhang Y, Thijssen V, Buijs N, Gao Y, Mateuszuk L, Fedak FA, Kij A, Campagna R, Sartini D, Emanuelli M, Chlopicki S, Jongkees SAK, Martin NI. van Haren MJ, et al. Among authors: buijs n. RSC Chem Biol. 2021 Aug 19;2(5):1546-1555. doi: 10.1039/d1cb00134e. eCollection 2021 Oct 7. RSC Chem Biol. 2021. PMID: 34704059 Free PMC article.
Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics.
Gao Y, van Haren MJ, Buijs N, Innocenti P, Zhang Y, Sartini D, Campagna R, Emanuelli M, Parsons RB, Jespers W, Gutiérrez-de-Terán H, van Westen GJP, Martin NI. Gao Y, et al. Among authors: buijs n. J Med Chem. 2021 Sep 9;64(17):12938-12963. doi: 10.1021/acs.jmedchem.1c01094. Epub 2021 Aug 23. J Med Chem. 2021. PMID: 34424711 Free PMC article.
Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.
Wood TM, Zeronian MR, Buijs N, Bertheussen K, Abedian HK, Johnson AV, Pearce NM, Lutz M, Kemmink J, Seirsma T, Hamoen LW, Janssen BJC, Martin NI. Wood TM, et al. Among authors: buijs n. Chem Sci. 2022 Feb 21;13(10):2985-2991. doi: 10.1039/d1sc07190d. eCollection 2022 Mar 9. Chem Sci. 2022. PMID: 35382464 Free PMC article.
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.
Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: buijs np. ACS Chem Biol. 2024 Apr 11. doi: 10.1021/acschembio.4c00034. Online ahead of print. ACS Chem Biol. 2024. PMID: 38602492