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Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial.
Yamazaki T, Gunderson AJ, Gilchrist M, Whiteford M, Kiely MX, Hayman A, O'Brien D, Ahmad R, Manchio JV, Fox N, McCarty K, Phillips M, Brosnan E, Vaccaro G, Li R, Simon M, Bernstein E, McCormick M, Yamasaki L, Wu Y, Drokin A, Carnahan T, To Y, Redmond WL, Lee B, Louie J, Hansen E, Solhjem MC, Cramer J, Urba WJ, Gough MJ, Crittenden MR, Young KH. Yamazaki T, et al. Among authors: fox n. Lancet Oncol. 2022 Sep;23(9):1189-1200. doi: 10.1016/S1470-2045(22)00446-6. Epub 2022 Aug 8. Lancet Oncol. 2022. PMID: 35952709 Clinical Trial.
TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking.
Gunderson AJ, Yamazaki T, McCarty K, Fox N, Phillips M, Alice A, Blair T, Whiteford M, O'Brien D, Ahmad R, Kiely MX, Hayman A, Crocenzi T, Gough MJ, Crittenden MR, Young KH. Gunderson AJ, et al. Among authors: fox n. Nat Commun. 2020 Apr 9;11(1):1749. doi: 10.1038/s41467-020-15404-8. Nat Commun. 2020. PMID: 32273499 Free PMC article.