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Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment.
Elgiushy HR, Mohamed SH, Taha H, Sawaf H, Hassan Z, Abou-Taleb NA, El-Labbad EM, Hassan AS, Abouzid KAM, Hammad SF. Elgiushy HR, et al. Among authors: abou taleb na. Bioorg Chem. 2022 Mar;120:105646. doi: 10.1016/j.bioorg.2022.105646. Epub 2022 Jan 29. Bioorg Chem. 2022. PMID: 35134645
Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists.
Elgiushy HR, Abou-Taleb NA, Holz GG, Chepurny OG, Pirmettis I, Kakabakos S, Karageorgos V, Liapakis G, Albohy A, Abouzid KAM, Hammad SF. Elgiushy HR, et al. Among authors: abou taleb na. Bioorg Chem. 2021 Sep;114:105079. doi: 10.1016/j.bioorg.2021.105079. Epub 2021 Jun 10. Bioorg Chem. 2021. PMID: 34174633 Free PMC article.
Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer.
Abdelsalam EA, Abd El-Hafeez AA, Eldehna WM, El Hassab MA, Marzouk HMM, Elaasser MM, Abou Taleb NA, Amin KM, Abdel-Aziz HA, Ghosh P, Hammad SF. Abdelsalam EA, et al. Among authors: abou taleb na. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2265-2282. doi: 10.1080/14756366.2022.2104841. J Enzyme Inhib Med Chem. 2022. PMID: 36000167 Free PMC article.
An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties.
Mohamed SH, Elgiushy HR, Taha H, Hammad SF, Abou-Taleb NA, A M Abouzid K, Al-Sawaf H, Hassan Z. Mohamed SH, et al. Among authors: abou taleb na. Bioorg Med Chem. 2020 Sep 1;28(17):115633. doi: 10.1016/j.bmc.2020.115633. Epub 2020 Jul 7. Bioorg Med Chem. 2020. PMID: 32773088