Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth.
Wan PK, Tong KC, Lok CN, Zhang C, Chang XY, Sze KH, Wong AST, Che CM.
Wan PK, et al.
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2025806118. doi: 10.1073/pnas.2025806118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33883283
Free PMC article.
Herein described is a highly effective antitumor and antimetastatic metal complex [Pt(II)(C^N^N)(NHC(2Bu))]PF(6) (Pt1a; HC^N^N = 6-phenyl-2,2'-bipyridine; NHC= N-heterocyclic carbene) that engages vimentin via noncovalent binding interactions with a di …
Herein described is a highly effective antitumor and antimetastatic metal complex [Pt(II)(C^N^N)(NHC(2Bu))]PF(6) (Pt1a; HC^ …