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Establishment of a reproducible and minimally invasive ischemic stroke model in swine.
Castaño C, Melià-Sorolla M, García-Serran A, DeGregorio-Rocasolano N, García-Sort MR, Hernandez-Pérez M, Valls-Carbó A, Pino O, Grífols J, Iruela-Sánchez A, Palomar-García A, Puig J, Martí-Sistac O, Dávalos A, Gasull T. Castaño C, et al. Among authors: degregorio rocasolano n. JCI Insight. 2023 Apr 24;8(8):e163398. doi: 10.1172/jci.insight.163398. JCI Insight. 2023. PMID: 36853828 Free PMC article.
Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice.
García-Serran A, Ordoño J, DeGregorio-Rocasolano N, Melià-Sorolla M, Odendaal K, Martí-Sistac O, Gasull T. García-Serran A, et al. Among authors: degregorio rocasolano n. Antioxidants (Basel). 2023 Oct 31;12(11):1945. doi: 10.3390/antiox12111945. Antioxidants (Basel). 2023. PMID: 38001798 Free PMC article.
Targeting Pro-Oxidant Iron with Deferoxamine as a Treatment for Ischemic Stroke: Safety and Optimal Dose Selection in a Randomized Clinical Trial.
Millán M, DeGregorio-Rocasolano N, Pérez de la Ossa N, Reverté S, Costa J, Giner P, Silva Y, Sobrino T, Rodríguez-Yáñez M, Nombela F, Campos F, Serena J, Vivancos J, Martí-Sistac O, Cortés J, Dávalos A, Gasull T. Millán M, et al. Among authors: degregorio rocasolano n. Antioxidants (Basel). 2021 Aug 10;10(8):1270. doi: 10.3390/antiox10081270. Antioxidants (Basel). 2021. PMID: 34439518 Free PMC article.
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
DeGregorio-Rocasolano N, Martí-Sistac O, Ponce J, Castelló-Ruiz M, Millán M, Guirao V, García-Yébenes I, Salom JB, Ramos-Cabrer P, Alborch E, Lizasoain I, Castillo J, Dávalos A, Gasull T. DeGregorio-Rocasolano N, et al. Redox Biol. 2018 May;15:143-158. doi: 10.1016/j.redox.2017.11.026. Epub 2017 Dec 2. Redox Biol. 2018. PMID: 29248829 Free PMC article. Clinical Trial.
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