Abstract
Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction. The authors describe complete remission of recurrent postprandial discomfort, nausea, and vomiting within 1 week of starting mirtazapine in a gastroparetic patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and/or tegaserod) and pyloric injection of botulinum toxin. This is the first report to show that mirtazapine may be an effective alternative when gastroparesis is refractory to conventional measures.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antidepressive Agents, Tricyclic / therapeutic use*
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Antiemetics / administration & dosage
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Depressive Disorder / drug therapy
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Depressive Disorder / etiology
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Diabetes Mellitus, Type 1 / complications
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Drug Resistance / drug effects*
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Erythromycin / administration & dosage
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Female
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Follow-Up Studies
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Gastrointestinal Agents / administration & dosage
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Gastroparesis / complications
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Gastroparesis / drug therapy*
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Gastroparesis / psychology
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Humans
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Lorazepam / administration & dosage
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Metoclopramide / administration & dosage
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Mianserin / analogs & derivatives*
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Mianserin / therapeutic use
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Mirtazapine
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Nausea / complications
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Nausea / drug therapy
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Nausea / psychology
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Severity of Illness Index
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Treatment Outcome
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Vomiting / complications
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Vomiting / drug therapy
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Vomiting / psychology
Substances
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Antidepressive Agents, Tricyclic
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Antiemetics
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Gastrointestinal Agents
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Mianserin
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Erythromycin
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Mirtazapine
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Metoclopramide
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Lorazepam