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Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
van der Wiel AMA, Jackson-Patel V, Niemans R, Yaromina A, Liu E, Marcus D, Mowday AM, Lieuwes NG, Biemans R, Lin X, Fu Z, Kumara S, Jochems A, Ashoorzadeh A, Anderson RF, Hicks KO, Bull MR, Abbattista MR, Guise CP, Deschoemaeker S, Thiolloy S, Heyerick A, Solivio MJ, Balbo S, Smaill JB, Theys J, Dubois LJ, Patterson AV, Lambin P. van der Wiel AMA, et al. Among authors: solivio mj. Mol Cancer Ther. 2021 Dec;20(12):2372-2383. doi: 10.1158/1535-7163.MCT-21-0406. Epub 2021 Oct 8. Mol Cancer Ther. 2021. PMID: 34625504 Free PMC article.
Base-modified thymidines capable of terminating DNA synthesis are novel bioactive compounds with activity in cancer cells.
Borland KM, AbdulSalam SF, Solivio MJ, Burke MP, Wolfkiel PR, Lawson SM, Stockman CA, Andersen JM, Smith S, Tolstolutskaya JN, Gurjar PN, Bercz AP, Merino EJ, Litosh VA. Borland KM, et al. Among authors: solivio mj. Bioorg Med Chem. 2015 Apr 15;23(8):1869-81. doi: 10.1016/j.bmc.2015.01.057. Epub 2015 Feb 14. Bioorg Med Chem. 2015. PMID: 25778768 Free PMC article.