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Page 1
A broadly protective antibody that targets the flavivirus NS1 protein.
Modhiran N, Song H, Liu L, Bletchly C, Brillault L, Amarilla AA, Xu X, Qi J, Chai Y, Cheung STM, Traves R, Setoh YX, Bibby S, Scott CAP, Freney ME, Newton ND, Khromykh AA, Chappell KJ, Muller DA, Stacey KJ, Landsberg MJ, Shi Y, Gao GF, Young PR, Watterson D. Modhiran N, et al. Among authors: freney me. Science. 2021 Jan 8;371(6525):190-194. doi: 10.1126/science.abb9425. Science. 2021. PMID: 33414219
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Among authors: freney me. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses.
Amarilla AA, Sng JDJ, Parry R, Deerain JM, Potter JR, Setoh YX, Rawle DJ, Le TT, Modhiran N, Wang X, Peng NYG, Torres FJ, Pyke A, Harrison JJ, Freney ME, Liang B, McMillan CLD, Cheung STM, Guevara DJDC, Hardy JM, Bettington M, Muller DA, Coulibaly F, Moore F, Hall RA, Young PR, Mackenzie JM, Hobson-Peters J, Suhrbier A, Watterson D, Khromykh AA. Amarilla AA, et al. Among authors: freney me. Nat Commun. 2021 Jun 8;12(1):3431. doi: 10.1038/s41467-021-23779-5. Nat Commun. 2021. PMID: 34103499 Free PMC article.
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2.
Amarilla AA, Modhiran N, Setoh YX, Peng NYG, Sng JDJ, Liang B, McMillan CLD, Freney ME, Cheung STM, Chappell KJ, Khromykh AA, Young PR, Watterson D. Amarilla AA, et al. Among authors: freney me. Front Microbiol. 2021 Feb 12;12:625136. doi: 10.3389/fmicb.2021.625136. eCollection 2021. Front Microbiol. 2021. PMID: 33643253 Free PMC article.
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis.
Slonchak A, Wang X, Aguado J, Sng JDJ, Chaggar H, Freney ME, Yan K, Torres FJ, Amarilla AA, Balea R, Setoh YX, Peng N, Watterson D, Wolvetang E, Suhrbier A, Khromykh AA. Slonchak A, et al. Among authors: freney me. Sci Adv. 2022 Dec 2;8(48):eadd8095. doi: 10.1126/sciadv.add8095. Epub 2022 Nov 30. Sci Adv. 2022. PMID: 36449607 Free PMC article.
Determinants of Zika virus host tropism uncovered by deep mutational scanning.
Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA. Setoh YX, et al. Among authors: freney me. Nat Microbiol. 2019 May;4(5):876-887. doi: 10.1038/s41564-019-0399-4. Epub 2019 Mar 18. Nat Microbiol. 2019. PMID: 30886357 Free PMC article.
Absence of Anti-RBD Antibodies in SARS-CoV-2 Infected or Naive Individuals Prior to Vaccination with CoronaVac Leads to Short Protection of Only Four Months Duration.
Oliveira CF, Neto WFF, Silva CPD, Ribeiro ACS, Martins LC, Sousa AW, Freitas MNO, Chiang JO, Silva FA, Santos EBD, Medeiros DBA, Pinheiro GS, Brandão GF, Carvalho VL, Azevedo RSS, Vasconcelos PFC, Costa IB, Costa IB, Santos MCD, Soares LS, Bedran RLS, Ferreira JL, Amarilla AA, Modhiran N, McMillan CLD, Freney ME, Muller DA, Watterson D, Casseb LMN, Henriques DF. Oliveira CF, et al. Among authors: freney me. Vaccines (Basel). 2022 Apr 28;10(5):690. doi: 10.3390/vaccines10050690. Vaccines (Basel). 2022. PMID: 35632447 Free PMC article.