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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 2
1952 4
1953 2
1954 3
1955 1
1957 2
1958 5
1959 2
1961 4
1962 3
1963 11
1964 8
1965 13
1966 18
1967 7
1968 13
1969 12
1970 11
1971 21
1972 17
1973 9
1974 18
1975 25
1976 28
1977 27
1978 35
1979 36
1980 28
1981 21
1982 18
1983 18
1984 18
1985 19
1986 30
1987 17
1988 36
1989 34
1990 24
1991 44
1992 45
1993 28
1994 36
1995 60
1996 48
1997 58
1998 56
1999 72
2000 86
2001 92
2002 109
2003 152
2004 155
2005 217
2006 221
2007 263
2008 358
2009 377
2010 453
2011 548
2012 566
2013 558
2014 549
2015 581
2016 591
2017 642
2018 614
2019 716
2020 770
2021 793
2022 709
2023 667
2024 250

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10,774 results

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The following term was not found in PubMed: Moo-Won
Page 1
The RNA-binding protein HuR in human cancer: A friend or foe?
Wu X, Xu L. Wu X, et al. Adv Drug Deliv Rev. 2022 May;184:114179. doi: 10.1016/j.addr.2022.114179. Epub 2022 Mar 3. Adv Drug Deliv Rev. 2022. PMID: 35248670 Free PMC article. Review.
Reduction of HuR levels in cancer cells leads to tumor regression in mouse xenograft models. ...This review summarizes the roles of HuR in cancer and other diseases, therapeutic potential of HuR inhibition, and the current status of drug discovery on HuR …
Reduction of HuR levels in cancer cells leads to tumor regression in mouse xenograft models. ...This review summarizes the roles of …
Targeting the RNA-Binding Protein HuR in Cancer.
Finan JM, Sutton TL, Dixon DA, Brody JR. Finan JM, et al. Cancer Res. 2023 Nov 1;83(21):3507-3516. doi: 10.1158/0008-5472.CAN-23-0972. Cancer Res. 2023. PMID: 37683260 Review.
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene expression at the posttranscriptional level. ...Exploiting the principles underlying HuR's role in tumorigenesis and resistance to stressors, targeting HuR has the potential …
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene expression at the posttranscriptional level. .. …
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, Chaerkady R, Wang J, Chiang A, Weng SHS, Tart J, Wong E, Donohoe G, Rawlins P, Gordon E, Taylor JD, James L, Hunt J. Fletcher A, et al. Nat Commun. 2023 Nov 4;14(1):7093. doi: 10.1038/s41467-023-42546-2. Nat Commun. 2023. PMID: 37925433 Free PMC article.
However, an effective small molecule antagonist to HuR for clinical use remains elusive. Here, a single domain antibody (VHH) that binds HuR with low nanomolar affinity was identified and shown to inhibit HuR binding to RNA. This VHH was used to engineer a TR …
However, an effective small molecule antagonist to HuR for clinical use remains elusive. Here, a single domain antibody (VHH) that bi …
MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR.
Chaudhary S, Appadurai MI, Maurya SK, Nallasamy P, Marimuthu S, Shah A, Atri P, Ramakanth CV, Lele SM, Seshacharyulu P, Ponnusamy MP, Nasser MW, Ganti AK, Batra SK, Lakshmanan I. Chaudhary S, et al. Breast Cancer Res. 2023 Mar 14;25(1):25. doi: 10.1186/s13058-023-01630-7. Breast Cancer Res. 2023. PMID: 36918912 Free PMC article.
Metastatic properties of MUC16 were evaluated using tail vein experiment. MUC16 and HuR downstream pathways were confirmed by ectopic overexpression of MUC16-carboxyl-terminal (MUC16-Cter), HuR and cMyc as well as HuR inhibitors (MS-444 and CMLD-2) in TNBC ce …
Metastatic properties of MUC16 were evaluated using tail vein experiment. MUC16 and HuR downstream pathways were confirmed by ectopic …
Posttranslational control of HuR function.
Grammatikakis I, Abdelmohsen K, Gorospe M. Grammatikakis I, et al. Wiley Interdiscip Rev RNA. 2017 Jan;8(1):10.1002/wrna.1372. doi: 10.1002/wrna.1372. Epub 2016 Jun 16. Wiley Interdiscip Rev RNA. 2017. PMID: 27307117 Free PMC article. Review.
The RNA-binding protein HuR (human antigen R) associates with numerous transcripts, coding and noncoding, and controls their splicing, localization, stability, and translation. ...In turn, HuR influences processes such as cancer and inflammation. HuR function …
The RNA-binding protein HuR (human antigen R) associates with numerous transcripts, coding and noncoding, and controls their splicing …
Relationship between HuR and tumor drug resistance.
Ma Q, Lu Q, Lei X, Zhao J, Sun W, Huang D, Zhu Q, Xu Q. Ma Q, et al. Clin Transl Oncol. 2023 Jul;25(7):1999-2014. doi: 10.1007/s12094-023-03109-5. Epub 2023 Mar 22. Clin Transl Oncol. 2023. PMID: 36947360 Review.
This review focuses on the relationship between HuR and drug resistance in different tumors and briefly describes the structure, function, and inhibitors of HuR. We summarize the mechanisms by which HuR causes tumor resistance and the molecular targets affect …
This review focuses on the relationship between HuR and drug resistance in different tumors and briefly describes the structure, func …
HuR as a molecular target for cancer therapeutics and immune-related disorders.
Majumder M, Chakraborty P, Mohan S, Mehrotra S, Palanisamy V. Majumder M, et al. Adv Drug Deliv Rev. 2022 Sep;188:114442. doi: 10.1016/j.addr.2022.114442. Epub 2022 Jul 8. Adv Drug Deliv Rev. 2022. PMID: 35817212 Free PMC article. Review.
HuR overexpression has been reported in many tumor types, which led to a poor prognosis for patients. Hence, HuR is considered an appealing drug target for cancer treatment. ...
HuR overexpression has been reported in many tumor types, which led to a poor prognosis for patients. Hence, HuR is considered …
HuR function in disease.
Srikantan S, Gorospe M. Srikantan S, et al. Front Biosci (Landmark Ed). 2012 Jan 1;17(1):189-205. doi: 10.2741/3921. Front Biosci (Landmark Ed). 2012. PMID: 22201738 Free PMC article. Review.
Here, we review the mechanisms that control HuR function, its influence on target mRNAs, and how impairment in HuR-governed gene expression programs impact upon different disease processes. We focus on HuR's well-recognized implication in cancer and chronic i …
Here, we review the mechanisms that control HuR function, its influence on target mRNAs, and how impairment in HuR-governed ge …
Multiple functions of HuR in urinary tumors.
Zhang F, Cai Z, Lv H, Li W, Liang M, Wei X, Zhou F. Zhang F, et al. J Cancer Res Clin Oncol. 2019 Jan;145(1):11-18. doi: 10.1007/s00432-018-2778-2. Epub 2018 Oct 28. J Cancer Res Clin Oncol. 2019. PMID: 30370480 Review.
Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment. CONCLUSION: HuR is associated with various …
Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a …
HuR as Therapeutic Target in Cancer: What the Future Holds.
Goutas D, Pergaris A, Giaginis C, Theocharis S. Goutas D, et al. Curr Med Chem. 2022;29(1):56-65. doi: 10.2174/0929867328666210628143430. Curr Med Chem. 2022. PMID: 34182901 Review.
Novel agents, interfering with HuR expression, have been tested, both in vitro and in vivo, with promising results. ...PubMed database was thoroughly searched, and all published articles providing scientific data on molecules that can exhibit antitumorigenic effects via …
Novel agents, interfering with HuR expression, have been tested, both in vitro and in vivo, with promising results. ...PubMed databas …
10,774 results
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