Numerical Solution for Fuzzy Time-Fractional Cancer Tumor Model with a Time-Dependent Net Killing Rate of Cancer Cells

Int J Environ Res Public Health. 2023 Feb 20;20(4):3766. doi: 10.3390/ijerph20043766.

Abstract

A cancer tumor model is an important tool for studying the behavior of various cancer tumors. Recently, many fuzzy time-fractional diffusion equations have been employed to describe cancer tumor models in fuzzy conditions. In this paper, an explicit finite difference method has been developed and applied to solve a fuzzy time-fractional cancer tumor model. The impact of using the fuzzy time-fractional derivative has been examined under the double parametric form of fuzzy numbers rather than using classical time derivatives in fuzzy cancer tumor models. In addition, the stability of the proposed model has been investigated by applying the Fourier method, where the net killing rate of the cancer cells is only time-dependent, and the time-fractional derivative is Caputo's derivative. Moreover, certain numerical experiments are discussed to examine the feasibility of the new approach and to check the related aspects. Over and above, certain needs in studying the fuzzy fractional cancer tumor model are detected to provide a better comprehensive understanding of the behavior of the tumor by utilizing several fuzzy cases on the initial conditions of the proposed model.

Keywords: Caputo formula; cancer tumor models; finite difference scheme; fuzzy fractional diffusion equation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diffusion
  • Humans
  • Neoplasms*

Grants and funding

The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (23UQU4282396DSR004).