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Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
Development of a novel conjugatable sunitinib analogue validated through in vitro and in vivo preclinical settings.
El Mubarak MA, Leontari I, Efstathia G, Vrettos EI, Shaikh AK, Konstantinos SE, Danika C, Kalofonos HP, Tzakos AG, Sivolapenko GB. El Mubarak MA, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:515-523. doi: 10.1016/j.jchromb.2018.05.050. Epub 2018 Jun 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 30008308