Characterization and Investigation of Novel Benzodioxol Derivatives as Antidiabetic Agents: An In Vitro and In Vivo Study in an Animal Model.
Hawash M, Al-Smadi D, Kumar A, Olech B, Dominiak PM, Jaradat N, Antari S, Mohammed S, Nasasrh A, Abualhasan M, Musa A, Suboh S, Çapan İ, Qneibi M, Natsheh H.
Hawash M, et al.
Biomolecules. 2023 Oct 6;13(10):1486. doi: 10.3390/biom13101486.
Biomolecules. 2023.
PMID: 37892167
Free PMC article.
Notably, IIa and IIc displayed potent alpha-amylase inhibition (IC(50) values of 0.85 and 0.68 M, respectively) while exhibiting a negligible effect on the Hek293t normal cell line (IC(50) > 150 M), suggesting their safety. Compound IId demonstrated significant a …
Notably, IIa and IIc displayed potent alpha-amylase inhibition (IC(50) values of 0.85 and 0.68 M, respectively) while exhibiting a ne …