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Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages.
Ogawa N, Nakajima S, Tamada K, Yokoue N, Tachibana H, Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Sato A, Kamiya T, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Ogawa N, et al. Among authors: okazawa m. Arch Biochem Biophys. 2021 Oct 30;711:109029. doi: 10.1016/j.abb.2021.109029. Epub 2021 Sep 10. Arch Biochem Biophys. 2021. PMID: 34517011
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors.
Tanuma SI, Katsuragi K, Oyama T, Yoshimori A, Shibasaki Y, Asawa Y, Yamazaki H, Makino K, Okazawa M, Ogino Y, Sakamoto Y, Nomura M, Sato A, Abe H, Nakamura H, Takahashi H, Tanuma N, Uchiumi F. Tanuma SI, et al. Among authors: okazawa m. Molecules. 2020 Aug 10;25(16):3633. doi: 10.3390/molecules25163633. Molecules. 2020. PMID: 32785052 Free PMC article.
A Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling.
Tanuma SI, Oyama T, Okazawa M, Yamazaki H, Takao K, Sugita Y, Amano S, Abe T, Sakagami H. Tanuma SI, et al. Among authors: okazawa m. Int J Mol Sci. 2022 Mar 22;23(7):3426. doi: 10.3390/ijms23073426. Int J Mol Sci. 2022. PMID: 35408786 Free PMC article.
Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways.
Nakajima S, Ogawa N, Yokoue N, Tachibana H, Tamada K, Okazawa M, Sato A, Oyama T, Abe H, Kamiya T, Yoshimori A, Yoshizawa K, Inoue S, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Nakajima S, et al. Among authors: okazawa m. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1155-1161. doi: 10.1016/j.bbrc.2020.09.126. Epub 2020 Oct 8. Biochem Biophys Res Commun. 2020. PMID: 33041002