Abstract
A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / toxicity
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / pharmacology
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Benzodiazepines / toxicity
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Fibroblasts / physiology
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Humans
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Pyrroles / toxicity
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Sincalide / metabolism
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
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Triazoles / toxicity
Substances
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Antineoplastic Agents
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Pyrroles
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Triazoles
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Benzodiazepines
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Sincalide