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Year Number of Results
1999 1
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2001 1
2003 1
2005 1
2006 1
2007 3
2008 3
2009 1
2010 1
2011 2
2012 3
2013 6
2014 9
2015 7
2016 8
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2023 28
2024 6

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144 results

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Page 1
Showing results for mihai profile
Search for Mihai Profire instead (3 results)
Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.
Distler O, Highland KB, Gahlemann M, Azuma A, Fischer A, Mayes MD, Raghu G, Sauter W, Girard M, Alves M, Clerisme-Beaty E, Stowasser S, Tetzlaff K, Kuwana M, Maher TM; SENSCIS Trial Investigators. Distler O, et al. N Engl J Med. 2019 Jun 27;380(26):2518-2528. doi: 10.1056/NEJMoa1903076. Epub 2019 May 20. N Engl J Med. 2019. PMID: 31112379 Free article. Clinical Trial.
CONCLUSIONS: Among patients with ILD associated with systemic sclerosis, the annual rate of decline in FVC was lower with nintedanib than with placebo; no clinical benefit of nintedanib was observed for other manifestations of systemic sclerosis. The adverse-event profile …
CONCLUSIONS: Among patients with ILD associated with systemic sclerosis, the annual rate of decline in FVC was lower with nintedanib than wi …
Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.
Khanna D, Lin CJF, Furst DE, Goldin J, Kim G, Kuwana M, Allanore Y, Matucci-Cerinic M, Distler O, Shima Y, van Laar JM, Spotswood H, Wagner B, Siegel J, Jahreis A, Denton CP; focuSSced investigators. Khanna D, et al. Lancet Respir Med. 2020 Oct;8(10):963-974. doi: 10.1016/S2213-2600(20)30318-0. Epub 2020 Aug 28. Lancet Respir Med. 2020. PMID: 32866440 Clinical Trial.
Findings for the secondary endpoint of FVC% predicted indicate that tocilizumab might preserve lung function in people with early SSc-ILD and elevated acute-phase reactants. Safety was consistent with the known profile of tocilizumab. FUNDING: F Hoffmann-La Roche Ltd....
Findings for the secondary endpoint of FVC% predicted indicate that tocilizumab might preserve lung function in people with early SSc-ILD an …
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG. Cheng SC, et al. Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684. Science. 2014. PMID: 25258083 Free PMC article.
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using histone modification profiles of human monocytes trained with the Candida albicans cell wall constituent beta-glucan, together with a …
Epigenetic reprogramming of myeloid cells, also known as trained immunity, confers nonspecific protection from secondary infections. Using h …
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates.
Sabnis S, Kumarasinghe ES, Salerno T, Mihai C, Ketova T, Senn JJ, Lynn A, Bulychev A, McFadyen I, Chan J, Almarsson Ö, Stanton MG, Benenato KE. Sabnis S, et al. Mol Ther. 2018 Jun 6;26(6):1509-1519. doi: 10.1016/j.ymthe.2018.03.010. Epub 2018 Mar 14. Mol Ther. 2018. PMID: 29653760 Free PMC article.
However, there are concerns whether an acceptable tolerability profile for chronic dosing can be achieved. The efficiency and tolerability of lipid nanoparticles has been attributed to the amino lipid. ...
However, there are concerns whether an acceptable tolerability profile for chronic dosing can be achieved. The efficiency and tolerab …
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ. Schirmer M, et al. Cell. 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. Cell. 2016. PMID: 27814509 Free PMC article.
Narrative Review: Update on the Molecular Diagnosis of Fragile X Syndrome.
Ciobanu CG, Nucă I, Popescu R, Antoci LM, Caba L, Ivanov AV, Cojocaru KA, Rusu C, Mihai CT, Pânzaru MC. Ciobanu CG, et al. Int J Mol Sci. 2023 May 24;24(11):9206. doi: 10.3390/ijms24119206. Int J Mol Sci. 2023. PMID: 37298158 Free PMC article. Review.
Long-range sequencing represented by PacBio and Oxford Nanopore has the potential to replace the actual diagnosis and offers a complete characterization of molecular profiles in a single test. The new technologies have improved the diagnosis of fragile X syndrome and revea …
Long-range sequencing represented by PacBio and Oxford Nanopore has the potential to replace the actual diagnosis and offers a complete char …
Porphyrin Macrocycles: General Properties and Theranostic Potential.
Boscencu R, Radulea N, Manda G, Machado IF, Socoteanu RP, Lupuliasa D, Burloiu AM, Mihai DP, Ferreira LFV. Boscencu R, et al. Molecules. 2023 Jan 23;28(3):1149. doi: 10.3390/molecules28031149. Molecules. 2023. PMID: 36770816 Free PMC article. Review.
This review focuses on studies of porphyrin macrocycles with regard to their structural and spectral profiles relevant to their applicability in efficient cancer diagnosis and therapy. ...
This review focuses on studies of porphyrin macrocycles with regard to their structural and spectral profiles relevant to their appli …
Cellular metabolism of myeloid cells in sepsis.
Arts RJ, Gresnigt MS, Joosten LA, Netea MG. Arts RJ, et al. J Leukoc Biol. 2017 Jan;101(1):151-164. doi: 10.1189/jlb.4MR0216-066R. Epub 2016 Jun 6. J Leukoc Biol. 2017. PMID: 27272310 Review.
In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial …
In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. …
144 results