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Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.
J Med Chem. 2010 Nov 11;53(21):7549-63. doi: 10.1021/jm1002292.
J Med Chem. 2010.
PMID: 20931963
Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS).
Asagarasu A, Matsui T, Hayashi H, Tamaoki S, Yamauchi Y, Sato M.
Asagarasu A, et al. Among authors: sato m.
Chem Pharm Bull (Tokyo). 2009 Jan;57(1):34-42. doi: 10.1248/cpb.57.34.
Chem Pharm Bull (Tokyo). 2009.
PMID: 19122313
Free article.
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Pharmacological properties of 3-amino-5,6,7,8-tetrahydro-2-[4-[4-(quinolin-2-yl)piperazin-1-yl]butyl]quinazolin-4(3H)-one (TZB-30878), a novel therapeutic agent for diarrhea-predominant irritable bowel syndrome (IBS) and its effects on an experimental IBS model.
Tamaoki S, Yamauchi Y, Nakano Y, Sakano S, Asagarasu A, Sato M.
Tamaoki S, et al. Among authors: sato m.
J Pharmacol Exp Ther. 2007 Sep;322(3):1315-23. doi: 10.1124/jpet.107.123729. Epub 2007 May 31.
J Pharmacol Exp Ther. 2007.
PMID: 17540858
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Magnetic sensing via ultrasonic excitation.
Yamada H, Takashima K, Ikushima K, Toida H, Sato M, Ishizawa Y.
Yamada H, et al. Among authors: sato m.
Rev Sci Instrum. 2013 Apr;84(4):044903. doi: 10.1063/1.4803188.
Rev Sci Instrum. 2013.
PMID: 23635223
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Biotransformation of 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a novel 5-hydroxytryptamine (5-HT)1A agonist/5-HT3 antagonist, in human hepatic cytochrome P450 enzymes.
Minato K, Suzuki R, Asagarasu A, Matsui T, Sato M.
Minato K, et al. Among authors: sato m.
Drug Metab Dispos. 2008 May;36(5):831-40. doi: 10.1124/dmd.107.018168. Epub 2008 Jan 31.
Drug Metab Dispos. 2008.
PMID: 18238859
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