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Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.
O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M. O'Malley DM, et al. J Clin Oncol. 2022 Mar 1;40(7):752-761. doi: 10.1200/JCO.21.01874. Epub 2022 Jan 6. J Clin Oncol. 2022. PMID: 34990208 Free PMC article. Clinical Trial.
We report efficacy and safety outcomes for patients with MSI-H/dMMR endometrial cancer enrolled in KEYNOTE-158. METHODS: Eligible patients from cohorts D (endometrial cancer, regardless of MSI-H/dMMR status) and K (any MSI-H/dMMR solid tumor, except colorecta …
We report efficacy and safety outcomes for patients with MSI-H/dMMR endometrial cancer enrolled in KEYNOTE-158. METHODS: Eligible pat …
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krish… See abstract for full author list ➔ ATTACC Investigators, et al. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4. N Engl J Med. 2021. PMID: 34351721 Free PMC article. Clinical Trial.
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le G… See abstract for full author list ➔ REMAP-CAP Investigators, et al. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4. N Engl J Med. 2021. PMID: 34351722 Free PMC article. Clinical Trial.
De Novo and Dominantly Inherited SPTAN1 Mutations Cause Spastic Paraplegia and Cerebellar Ataxia.
Van de Vondel L, De Winter J, Beijer D, Coarelli G, Wayand M, Palvadeau R, Pauly MG, Klein K, Rautenberg M, Guillot-Noël L, Deconinck T, Vural A, Ertan S, Dogu O, Uysal H, Brankovic V, Herzog R, Brice A, Durr A, Klebe S, Stock F, Bischoff AT, Rattay TW, Sobrido MJ, De Michele G, De Jonghe P, Klopstock T, Lohmann K, Zanni G, Santorelli FM, Timmerman V, Haack TB, Züchner S; PREPARE Consortium; Schüle R, Stevanin G, Synofzik M, Basak AN, Baets J. Van de Vondel L, et al. Mov Disord. 2022 Jun;37(6):1175-1186. doi: 10.1002/mds.28959. Epub 2022 Feb 12. Mov Disord. 2022. PMID: 35150594 Free PMC article.
Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device.
Kirk C, Küderle A, Micó-Amigo ME, Bonci T, Paraschiv-Ionescu A, Ullrich M, Soltani A, Gazit E, Salis F, Alcock L, Aminian K, Becker C, Bertuletti S, Brown P, Buckley E, Cantu A, Carsin AE, Caruso M, Caulfield B, Cereatti A, Chiari L, D'Ascanio I, Garcia-Aymerich J, Hansen C, Hausdorff JM, Hiden H, Hume E, Keogh A, Kluge F, Koch S, Maetzler W, Megaritis D, Mueller A, Niessen M, Palmerini L, Schwickert L, Scott K, Sharrack B, Sillén H, Singleton D, Vereijken B, Vogiatzis I, Yarnall AJ, Rochester L, Mazzà C, Eskofier BM, Del Din S; Mobilise-D consortium. Kirk C, et al. Sci Rep. 2024 Jan 19;14(1):1754. doi: 10.1038/s41598-024-51766-5. Sci Rep. 2024. PMID: 38243008 Free PMC article.
Participants with Parkinson's Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and healthy older adults (n = 97) were monitored in the laboratory and the real-world (2.5 h), using a lower back wearable …
Participants with Parkinson's Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Disease, Congestive Hear …
Earlier snowmelt may lead to late season declines in plant productivity and carbon sequestration in Arctic tundra ecosystems.
Zona D, Lafleur PM, Hufkens K, Bailey B, Gioli B, Burba G, Goodrich JP, Liljedahl AK, Euskirchen ES, Watts JD, Farina M, Kimball JS, Heimann M, Göckede M, Pallandt M, Christensen TR, Mastepanov M, López-Blanco E, Jackowicz-Korczynski M, Dolman AJ, Marchesini LB, Commane R, Wofsy SC, Miller CE, Lipson DA, Hashemi J, Arndt KA, Kutzbach L, Holl D, Boike J, Wille C, Sachs T, Kalhori A, Song X, Xu X, Humphreys ER, Koven CD, Sonnentag O, Meyer G, Gosselin GH, Marsh P, Oechel WC. Zona D, et al. Sci Rep. 2022 Mar 21;12(1):3986. doi: 10.1038/s41598-022-07561-1. Sci Rep. 2022. PMID: 35314726 Free PMC article.
Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.
Acernese F, Agathos M, Ain A, Albanesi S, Alléné C, Allocca A, Amato A, Amra C, Andia M, Andrade T, Andres N, Andrés-Carcasona M, Andrić T, Ansoldi S, Antier S, Apostolatos T, Appavuravther EZ, Arène M, Arnaud N, Assiduo M, Melo SAS, Astone P, Aubin F, Babak S, Badaracco F, Bagnasco S, Baird J, Baka T, Ballardin G, Baltus G, Banerjee B, Barneo P, Barone F, Barsuglia M, Barta D, Basti A, Bawaj M, Bazzan M, Beirnaert F, Bejger M, Benedetto V, Berbel M, Bernuzzi S, Bersanetti D, Bertolini A, Bhardwaj U, Bianchi A, Bilicki M, Bini S, Bischi M, Bitossi M, Bizouard MA, Bobba F, Boër M, Bogaert G, Boileau G, Boldrini M, Bonavena LD, Bondarescu R, Bondu F, Bonnand R, Boschi V, Boudart V, Bouffanais Y, Bozzi A, Bradaschia C, Braglia M, Branchesi M, Breschi M, Briant T, Brillet A, Brooks J, Bruno G, Bucci F, Bulashenko O, Bulik T, Bulten HJ, Buscicchio R, Buskulic D, Buy C, Cabras G, Cabrita R, Cagnoli G, Calloni E, Canepa M, Santoro GC, Cannavacciuolo M, Capocasa E, Carapella G, Carbognani F, Carpinelli M, Carullo G, Diaz JC, Casentini C, Caudill S, Cavalieri R, Cella G, Cerdá-Durán P, Cesarini E, Chaibi W, Chanial P, Chassande-Mottin E, Chaty S, Chessa P, Chiadini F, Chiarini G, Chierici … See abstract for full author list ➔ Acernese F, et al. Phys Rev Lett. 2023 Jul 28;131(4):041403. doi: 10.1103/PhysRevLett.131.041403. Phys Rev Lett. 2023. PMID: 37566847
Development and Clinical Evaluation of a Rapid Point of Care Test for Ebola Virus Infection in Humans.
Wang Z, Bennett RS, Roehler M, Guillon G, Fischl MJ, Donadi MC, Makovetz J, Holmes N, Zaveri T, Toolan E, Gontz HL, Yearwood GD, Logue J, Bohannon JK, Mistretta L, Byrum R, Ragland D, St Claire M, Kurtz LA, Miller T, Reed MR, Young J, Lee J, Hensley LE, Kardos K, Berry JD. Wang Z, et al. Viruses. 2023 Jan 25;15(2):336. doi: 10.3390/v15020336. Viruses. 2023. PMID: 36851550 Free PMC article.
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis.
Moro L, Simoneschi D, Kurz E, Arbini AA, Jang S, Guaragnella N, Giannattasio S, Wang W, Chen YA, Pires G, Dang A, Hernandez E, Kapur P, Mishra A, Tsirigos A, Miller G, Hsieh JT, Pagano M. Moro L, et al. Nat Cell Biol. 2020 Sep;22(9):1130-1142. doi: 10.1038/s41556-020-0560-6. Epub 2020 Aug 24. Nat Cell Biol. 2020. PMID: 32839549 Free PMC article.
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