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Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Bortolomeazzi M, Keddar MR, Montorsi L, Acha-Sagredo A, Benedetti L, Temelkovski D, Choi S, Petrov N, Todd K, Wai P, Kohl J, Denner T, Nye E, Goldstone R, Ward S, Wilson GA, Al Bakir M, Swanton C, John S, Miles J, Larijani B, Kunene V, Fontana E, Arkenau HT, Parker PJ, Rodriguez-Justo M, Shiu KK, Spencer J, Ciccarelli FD. Bortolomeazzi M, et al. Gastroenterology. 2021 Oct;161(4):1179-1193. doi: 10.1053/j.gastro.2021.06.064. Epub 2021 Jun 29. Gastroenterology. 2021. PMID: 34197832 Free PMC article.
Identification of non-cancer cells from cancer transcriptomic data.
Bortolomeazzi M, Keddar MR, Ciccarelli FD, Benedetti L. Bortolomeazzi M, et al. Biochim Biophys Acta Gene Regul Mech. 2020 Jun;1863(6):194445. doi: 10.1016/j.bbagrm.2019.194445. Epub 2019 Oct 22. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 31654804 Free PMC article. Review.
Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.
Ghasemi DR, Okonechnikov K, Rademacher A, Tirier S, Maass KK, Schumacher H, Joshi P, Gold MP, Sundheimer J, Statz B, Rifaioglu AS, Bauer K, Schumacher S, Bortolomeazzi M, Giangaspero F, Ernst KJ, Clifford SC, Saez-Rodriguez J, Jones DTW, Kawauchi D, Fraenkel E, Mallm JP, Rippe K, Korshunov A, Pfister SM, Pajtler KW. Ghasemi DR, et al. Among authors: bortolomeazzi m. Nat Commun. 2024 Jan 8;15(1):269. doi: 10.1038/s41467-023-44117-x. Nat Commun. 2024. PMID: 38191550 Free PMC article.
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource.
Dressler L, Bortolomeazzi M, Keddar MR, Misetic H, Sartini G, Acha-Sagredo A, Montorsi L, Wijewardhane N, Repana D, Nulsen J, Goldman J, Pollitt M, Davis P, Strange A, Ambrose K, Ciccarelli FD. Dressler L, et al. Among authors: bortolomeazzi m. Genome Biol. 2022 Jan 26;23(1):35. doi: 10.1186/s13059-022-02607-z. Genome Biol. 2022. PMID: 35078504 Free PMC article. Review.
Rarity: discovering rare cell populations from single-cell imaging data.
Märtens K, Bortolomeazzi M, Montorsi L, Spencer J, Ciccarelli F, Yau C. Märtens K, et al. Among authors: bortolomeazzi m. Bioinformatics. 2023 Dec 1;39(12):btad750. doi: 10.1093/bioinformatics/btad750. Bioinformatics. 2023. PMID: 38092048 Free PMC article.