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A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N. Reynaud S, et al. Among authors: degueldre m. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32602722
Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins.
Amorim FG, Longhim HT, Cologna CT, Degueldre M, Pauw E, Quinton L, Arantes EC. Amorim FG, et al. Among authors: degueldre m. J Venom Anim Toxins Incl Trop Dis. 2019 Apr 18;25:e148218. doi: 10.1590/1678-9199-JVATITD-1482-18. eCollection 2019. J Venom Anim Toxins Incl Trop Dis. 2019. PMID: 31131005 Free PMC article.
Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics.
Degueldre M, Verdenaud M, Legarda G, Minambres R, Zuniga S, Leblanc M, Gilles N, Ducancel F, De Pauw E, Quinton L. Degueldre M, et al. Toxicon. 2017 May;130:116-125. doi: 10.1016/j.toxicon.2017.02.014. Epub 2017 Feb 20. Toxicon. 2017. PMID: 28223047
13 results