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Page 1
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
J Med Chem. 2021 Sep 23;64(18):13793-13806. doi: 10.1021/acs.jmedchem.1c01178. Epub 2021 Sep 2.
J Med Chem. 2021.
PMID: 34473502
An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
Buša M, Matoušková Z, Bartošová-Sojková P, Pachl P, Řezáčová P, Eichenberger RM, Deplazes P, Horn M, Štefanić S, Mareš M.
Buša M, et al.
J Biol Chem. 2023 Mar;299(3):102970. doi: 10.1016/j.jbc.2023.102970. Epub 2023 Feb 1.
J Biol Chem. 2023.
PMID: 36736427
Free PMC article.
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The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.
Kotál J, Stergiou N, Buša M, Chlastáková A, Beránková Z, Řezáčová P, Langhansová H, Schwarz A, Calvo E, Kopecký J, Mareš M, Schmitt E, Chmelař J, Kotsyfakis M.
Kotál J, et al. Among authors: busa m.
Cell Mol Life Sci. 2019 May;76(10):2003-2013. doi: 10.1007/s00018-019-03034-3. Epub 2019 Feb 12.
Cell Mol Life Sci. 2019.
PMID: 30747251
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Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host.
Martins LA, Buša M, Chlastáková A, Kotál J, Beránková Z, Stergiou N, Jmel MA, Schmitt E, Chmelař J, Mareš M, Kotsyfakis M.
Martins LA, et al. Among authors: busa m.
Cell Mol Life Sci. 2023 Oct 28;80(11):339. doi: 10.1007/s00018-023-04993-4.
Cell Mol Life Sci. 2023.
PMID: 37898573
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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Benýšek J, Buša M, Rubešová P, Fanfrlík J, Lepšík M, Brynda J, Matoušková Z, Bartz U, Horn M, Gütschow M, Mareš M.
Benýšek J, et al. Among authors: busa m.
J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526. doi: 10.1080/14756366.2021.2024527.
J Enzyme Inhib Med Chem. 2022.
PMID: 35144520
Free PMC article.
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Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion.
Kotál J, Buša M, Urbanová V, Řezáčová P, Chmelař J, Langhansová H, Sojka D, Mareš M, Kotsyfakis M.
Kotál J, et al. Among authors: busa m.
Int J Mol Sci. 2021 May 20;22(10):5371. doi: 10.3390/ijms22105371.
Int J Mol Sci. 2021.
PMID: 34065290
Free PMC article.
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An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
Matoušková Z, Orsághová K, Srb P, Pytelková J, Kukačka Z, Buša M, Hajdušek O, Šíma R, Fábry M, Novák P, Horn M, Kopáček P, Mareš M.
Matoušková Z, et al. Among authors: busa m.
Int J Mol Sci. 2024 Feb 13;25(4):2240. doi: 10.3390/ijms25042240.
Int J Mol Sci. 2024.
PMID: 38396918
Free PMC article.
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