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Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Needham EJ, Ren AL, Digby RJ, Norton EJ, Ebrahimi S, Outtrim JG, Chatfield DA, Manktelow AE, Leibowitz MM, Newcombe VFJ, Doffinger R, Barcenas-Morales G, Fonseca C, Taussig MJ, Burnstein RM, Samanta RJ, Dunai C, Sithole N, Ashton NJ, Zetterberg H, Gisslén M, Edén A, Marklund E, Openshaw PJM, Dunning J, Griffiths MJ, Cavanagh J, Breen G, Irani SR, Elmer A, Kingston N, Summers C, Bradley JR, Taams LS, Michael BD, Bullmore ET, Smith KGC, Lyons PA, Coles AJ, Menon DK; Cambridge NeuroCOVID Group; CITIID-NIHR COVID-19 BioResource Collaboration; Cambridge NIHR Clinical Research Facility. Needham EJ, et al. Brain. 2022 Nov 21;145(11):4097-4107. doi: 10.1093/brain/awac321. Brain. 2022. PMID: 36065116 Free PMC article.
Prostanoids with cyclopentenone structure as tools for the characterization of electrophilic lipid-protein interactomes.
Stamatakis K, Pérez-Sala D. Stamatakis K, et al. Ann N Y Acad Sci. 2006 Dec;1091:548-70. doi: 10.1196/annals.1378.096. Ann N Y Acad Sci. 2006. PMID: 17341644 Review.
Cyclopentenone prostaglandins (cyPG) and isoprostanes are reactive eicosanoids that can form covalent adducts with cysteine residues in proteins through Michael addition. In pharmacological studies, cyPG have shown potent protective effects in experimental models of inflam …
Cyclopentenone prostaglandins (cyPG) and isoprostanes are reactive eicosanoids that can form covalent adducts with cysteine residues in prot …