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Page 1
Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals.
Amin N, Liu J, Bonnechere B, MahmoudianDehkordi S, Arnold M, Batra R, Chiou YJ, Fernandes M, Ikram MA, Kraaij R, Krumsiek J, Newby D, Nho K, Radjabzadeh D, Saykin AJ, Shi L, Sproviero W, Winchester L, Yang Y, Nevado-Holgado AJ, Kastenmüller G, Kaddurah-Daouk R, van Duijn CM. Amin N, et al. JAMA Psychiatry. 2023 Jun 1;80(6):597-609. doi: 10.1001/jamapsychiatry.2023.0685. JAMA Psychiatry. 2023. PMID: 37074710
MAIN OUTCOMES AND MEASURES: Outcomes were lifetime and recurrent MDD, with 249 metabolites profiled with nuclear magnetic resonance spectroscopy with the Nightingale platform. ...Individuals with lifetime MDD were younger (median [IQR] age, 56 [49-62] years vs 58 [51-64] y …
MAIN OUTCOMES AND MEASURES: Outcomes were lifetime and recurrent MDD, with 249 metabolites profiled with nuclear magnetic resonance s …
MR spectroscopy in pediatric neuroradiology.
Liserre R, Pinelli L, Gasparotti R. Liserre R, et al. Transl Pediatr. 2021 Apr;10(4):1169-1200. doi: 10.21037/tp-20-445. Transl Pediatr. 2021. PMID: 34012861 Free PMC article. Review.
Magnetic resonance spectroscopy (MRS), being able to identify and measure some brain components (metabolites) in pathologic lesions and in normal-appearing tissue, offers a valuable additional diagnostic tool to assess several pediatric neurological diseases. ...
Magnetic resonance spectroscopy (MRS), being able to identify and measure some brain components (metabolites) in pathologic lesions a …
Immune checkpoint inhibitors in lymphoma: challenges and opportunities.
Hatic H, Sampat D, Goyal G. Hatic H, et al. Ann Transl Med. 2021 Jun;9(12):1037. doi: 10.21037/atm-20-6833. Ann Transl Med. 2021. PMID: 34277837 Free PMC article. Review.
The underlying reasons for the low efficacy of ICI monotherapy in most lymphomas may include defects in antigen presentation, non-inflamed tumor microenvironment (TME), immunosuppressive metabolites, genetic factors, and an overall lack of predictive biomarkers of response …
The underlying reasons for the low efficacy of ICI monotherapy in most lymphomas may include defects in antigen presentation, non-inflamed t …
Future diagnostics in male infertility: genomics, epigenetics, metabolomics and proteomics.
Krzastek SC, Smith RP, Kovac JR. Krzastek SC, et al. Transl Androl Urol. 2020 Mar;9(Suppl 2):S195-S205. doi: 10.21037/tau.2019.10.20. Transl Androl Urol. 2020. PMID: 32257860 Free PMC article. Review.
The study of the genes involved, the impact of epigenetic modifications, proteins and metabolites produced are attractive targets for development of biomarkers which may be used to diagnose the etiology of male infertility. ...
The study of the genes involved, the impact of epigenetic modifications, proteins and metabolites produced are attractive targets for …
Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration.
Bishop PL, Brescia S, Brunner R, Casey W, Conlee-Griffin K, Currie RA, Domoradzki J, Embry M, Harris MI, Hartung T, Hilton GM, Hooberman B, Ingle B, Jang KJ, Kinter L, Krall C, Leedale J, Lowit A, Mehta J, Mendez E, Mingoia B, Munarriz E, Murphy L, Myer A, Ottoni A, Panzarea M, Perron M, Pina J, Ramsingh D, Sewell F, Swanson J, Tan YM, Terron A, Trainer MA, Valadares MC, Webb S, Webb E, Willett C, Wolf DC. Bishop PL, et al. ALTEX. 2023;40(3):534-540. doi: 10.14573/altex.2302151. Epub 2023 Mar 8. ALTEX. 2023. PMID: 36888967 Free article.
Promising novel tools including in vitro comparative metabolism studies, in silico models, and high-throughput assays able to identify metabolites and mechanisms of action leading to development of adverse outcome pathways will need further development. ...
Promising novel tools including in vitro comparative metabolism studies, in silico models, and high-throughput assays able to identify me
Does microbiome shift play a role in carcinogenesis? A systematic review.
Mallika L, Augustine D, Rao RS, Patil S, Alamir AWH, Awan KH, Sowmya SV, Haragannavar VC, Prasad K. Mallika L, et al. Transl Cancer Res. 2020 Apr;9(4):3153-3166. doi: 10.21037/tcr.2020.02.11. Transl Cancer Res. 2020. PMID: 35117679 Free PMC article. Review.
Humans are hosts to multifarious microbial communities, and these resident microbes contribute to both health and disease. Circulating toxic metabolites from these resident microbes may contribute to the development and progression of cancer. ...
Humans are hosts to multifarious microbial communities, and these resident microbes contribute to both health and disease. Circulating toxic …
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.
Eisenbrand G, Baum M, Cartus AT, Diel P, Engel KH, Engeli B, Epe B, Grune T, Guth S, Haller D, Heinz V, Hellwig M, Hengstler JG, Henle T, Humpf HU, Jäger H, Joost HG, Kulling S, Lachenmeier DW, Lampen A, Leist M, Mally A, Marko D, Nöthlings U, Röhrdanz E, Roth A, Spranger J, Stadler R, Vieths S, Wätjen W, Steinberg P. Eisenbrand G, et al. Arch Toxicol. 2022 Jun;96(6):1905-1914. doi: 10.1007/s00204-022-03296-0. Epub 2022 May 4. Arch Toxicol. 2022. PMID: 35504979
Salivary excretion may also occur with certain drug molecules and food constituents and their metabolites. Therefore, putative combination effects in the oral cavity and the upper digestive tract may occur, but this has remained largely unexplored up to now. In this Guest …
Salivary excretion may also occur with certain drug molecules and food constituents and their metabolites. Therefore, putative combin …
Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues.
Teschke R, Uetrecht J. Teschke R, et al. Ann Transl Med. 2021 Apr;9(8):730. doi: 10.21037/atm-2020-ubih-05. Ann Transl Med. 2021. PMID: 33987428 Free PMC article. Review.
Similarly, exosomes are likely to play an important role in communication between hepatic cells and the immune system, but there is a lack of data on blood exosomes in affected patients. Reactive metabolites are likely to play an important role. This is supported by the cu …
Similarly, exosomes are likely to play an important role in communication between hepatic cells and the immune system, but there is a lack o …
The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer.
Naqash AR, Kihn-Alarcón AJ, Stavraka C, Kerrigan K, Maleki Vareki S, Pinato DJ, Puri S. Naqash AR, et al. Ann Transl Med. 2021 Jun;9(12):1034. doi: 10.21037/atm-20-6427. Ann Transl Med. 2021. PMID: 34277834 Free PMC article. Review.
Antibiotic or diet induced alterations in composition of the microbiome can also indirectly alter the production of certain bacterial metabolites such as deoxycholate and short chain fatty acids that can influence the anti-tumor tolerogenesis. ...
Antibiotic or diet induced alterations in composition of the microbiome can also indirectly alter the production of certain bacterial met
19 results