Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds

Molecules. 2013 May 14;18(5):5568-79. doi: 10.3390/molecules18055568.

Abstract

Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

MeSH terms

  • Animals
  • Cucurbita / chemistry*
  • Cytotoxins* / chemistry
  • Cytotoxins* / isolation & purification
  • Cytotoxins* / pharmacology
  • Dose-Response Relationship, Drug
  • HL-60 Cells
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / metabolism
  • Melanoma / pathology
  • Mice
  • Seeds / chemistry*
  • Triterpenes* / chemistry
  • Triterpenes* / isolation & purification
  • Triterpenes* / pharmacology

Substances

  • Cytotoxins
  • Triterpenes